Immunoglobulin diversity - Rearranging by cutting and repairing

被引:15
作者
Lieber, M [1 ]
机构
[1] WASHINGTON UNIV,SCH MED,DEPT BIOCHEM MOLEC BIOPHYS,ST LOUIS,MO 63110
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0960-9822(02)00443-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The recombination process that assembles antigen-receptor genes is now understood in some biochemical detail. The initial steps reflect a common theme seen in retroviral integration and prokaryotic transposition, and the later steps involve the enzymatic machinery for double-strand break DNA repair.
引用
收藏
页码:134 / 136
页数:3
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