The implications for childhood leukemia of infection with adenovirus

被引：9

作者：

Dorak, MT ^{[1
]}

机构：

[1] UNIV WALES COLL MED, DEPT HAEMATOL, CARDIFF CF4 4XN, S GLAM, WALES

来源：

TRENDS IN MICROBIOLOGY | 1996年 / 4卷 / 02期

关键词：

D O I：

10.1016/0966-842X(96)81512-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adenoviruses have mechanisms that allow persistence in lymphoid cells and immunoevasion. They downregulate major histocompatibility complex (MHC) class I antigen expression and may trigger an autoimmune reaction against MHC class II antigens through mimicry. Adenoviral persistence could be facilitated by human leukocyte antigens A2 and DR53, thereby allowing a preleukemic clone to escape immune surveillance and progress to leukemia.

引用

页码：60 / 63

页数：4

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