A subgroup of breast carcinomas is cytogenetically characterized by trisomy 12

Chromosome analysis of short-term cultured breast carcinoma cells revealed trisomy 22 in four cases. In one tumor it was the only abnormality. The second case showed cytogenetic polyclonality, but the mainline had +12 as the sole change. In the remaining two tumors, trisomy 12 was part of more complex karyotypes. These findings, especially when coupled with similar information on previously published cases, show that gain of chromosome it is a recurrent and sometimes early event in breast carcinogenesis. (C) Elsevier Science Inc., 1997.