Molecular Genetic Manipulation of Vector Mosquitoes

被引：52

作者：

Terenius, Olle ^{[1
]}

Marinotti, Osvaldo ^{[1
]}

Sieglaff, Douglas ^{[1
,2
]}

James, Anthony A. ^{[1
,3
]}

机构：

[1] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Inst Genom & Bioinformat, Irvine, CA 92697 USA

[3] Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA

来源：

CELL HOST & MICROBE | 2008年 / 4卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.chom.2008.09.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genetic strategies for reducing populations of vector mosquitoes or replacing them with those that are not able to transmit pathogens benefit greatly from molecular tools that allow gene manipulation and transgenesis. Mosquito genome sequences and associated EST (expressed sequence tags) databases enable large-scale investigations to provide new insights into evolutionary, biochemical, genetic, metabolic, and physiological pathways. Additionally, comparative genomics reveals the bases for evolutionary mechanisms with particular focus on specific interactions between vectors and pathogens. We discuss how this information may be exploited for the optimization of transgenes that interfere with the propagation and development of pathogens in their mosquito hosts.

引用

页码：417 / 423

页数：7

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