Accuracy, repeatability, and interplatform reproducibility of T1 quantification methods used for DCE-MRI: Results from a multicenter phantom study

被引:89
作者
Bane, Octavia [1 ,2 ]
Hectors, Stefanie J. [1 ,2 ]
Wagner, Mathilde [1 ,2 ]
Arlinghaus, Lori L. [3 ]
Aryal, Madhava P. [4 ]
Cao, Yue [4 ]
Chenevert, Thomas L. [5 ]
Fennessy, Fiona [6 ]
Huang, Wei [7 ]
Hylton, Nola M. [8 ]
Kalpathy-Cramer, Jayashree [9 ]
Keenan, Kathryn E. [10 ]
Malyarenko, Dariya I. [5 ]
Mulkern, Robert V. [6 ]
Newitt, David C. [8 ]
Russek, Stephen E. [10 ]
Stupic, Karl F. [10 ]
Tudorica, Alina [11 ]
Wilmes, Lisa J. [8 ]
Yankeelov, Thomas E. [12 ]
Yen, Yi-Fei [9 ]
Boss, Michael A. [10 ]
Taouli, Bachir [1 ,2 ]
机构
[1] Icahn Sch Med Mt Sinai, Translat & Mol Imaging Inst, One Gustave L Levy Pl,Box 1234, New York, NY 10029 USA
[2] Icahn Sch Med Mt Sinai, Dept Radiol, One Gustave L Levy Pl,Box 1234, New York, NY 10029 USA
[3] Vanderbilt Univ, Med Ctr, Nashville, TN USA
[4] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA
[5] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA
[6] Brigham & Womens Hosp, Dept Radiol, 75 Francis St, Boston, MA 02115 USA
[7] Oregon Hlth & Sci Univ, Knight Canc Inst, Adv Imaging Res Ctr, Portland, OR 97201 USA
[8] Univ Calif San Francisco, Dept Radiol, San Francisco, CA USA
[9] Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA
[10] NIST, Phys Measurement Lab, Boulder, CO USA
[11] Oregon Hlth & Sci Univ, Dept Radiol, Portland, OR 97201 USA
[12] Univ Texas Austin, Dept Radiol, Austin, TX 78712 USA
基金
美国国家卫生研究院;
关键词
T-1; mapping; DCE-MRI; phantom; multicenter; CONTRAST-ENHANCED MRI; RELAXATION-TIMES; LIVER-CIRRHOSIS; PROSTATE-CANCER; PARAMETERS; PERFUSION; DIFFUSION; PRECISION; UNCERTAINTY; ACQUISITION;
D O I
10.1002/mrm.26903
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
100231 [临床病理学]; 100902 [航空航天医学];
摘要
PurposeTo determine the in vitro accuracy, test-retest repeatability, and interplatform reproducibility of T-1 quantification protocols used for dynamic contrast-enhanced MRI at 1.5 and 3T. MethodsA T-1 phantom with 14 samples was imaged at eight centers with a common inversion-recovery spin-echo (IR-SE) protocol and a variable flip angle (VFA) protocol using seven flip angles, as well as site-specific protocols (VFA with different flip angles, variable repetition time, proton density, and Look-Locker inversion recovery). Factors influencing the accuracy (deviation from reference NMR T-1 measurements) and repeatability were assessed using general linear mixed models. Interplatform reproducibility was assessed using coefficients of variation. ResultsFor the common IR-SE protocol, accuracy (median error across platforms=1.4-5.5%) was influenced predominantly by T-1 sample (P<10(-6)), whereas test-retest repeatability (median error=0.2-8.3%) was influenced by the scanner (P<10(-6)). For the common VFA protocol, accuracy (median error=5.7-32.2%) was influenced by field strength (P=0.006), whereas repeatability (median error=0.7-25.8%) was influenced by the scanner (P<0.0001). Interplatform reproducibility with the common VFA was lower at 3T than 1.5T (P=0.004), and lower than that of the common IR-SE protocol (coefficient of variation 1.5T: VFA/IR-SE=11.13%/8.21%, P=0.028; 3T: VFA/IR-SE=22.87%/5.46%, P=0.001). Among the site-specific protocols, Look-Locker inversion recovery and VFA (2-3 flip angles) protocols showed the best accuracy and repeatability (errors<15%). ConclusionsThe VFA protocols with 2 to 3 flip angles optimized for different applications achieved acceptable balance of extensive spatial coverage, accuracy, and repeatability in T-1 quantification (errors<15%). Further optimization in terms of flip-angle choice for each tissue application, and the use of B-1 correction, are needed to improve the robustness of VFA protocols for T-1 mapping. Magn Reson Med 79:2564-2575, 2018. (c) 2017 International Society for Magnetic Resonance in Medicine.
引用
收藏
页码:2564 / 2575
页数:12
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