In vivo proton magnetic resonance spectroscopy of breast cancer: a review of the literature

被引：52

作者：

Begley, Jonathan K. P. ^{[2
]}

Redpath, Thomas W. ^{[3
]}

Bolan, Patrick J. ^{[4
]}

Gilbert, Fiona J. ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Radiol, Cambridge CB2 0QQ, England

[2] Univ Aberdeen, Sch Med & Dent, Aberdeen AB25 2ZD, Scotland

[3] Aberdeen Biomed Imaging Ctr, Sch Med, Aberdeen AB25 2ZD, Scotland

[4] Univ Minnesota, Ctr Magnet Resonance Res, Dept Radiol, Minneapolis, MN 55455 USA

来源：

BREAST CANCER RESEARCH | 2012年 / 14卷 / 02期

关键词：

H-1 MR SPECTROSCOPY; PREDICTING PATHOLOGICAL RESPONSE; CHOLINE-CONTAINING COMPOUNDS; NEOADJUVANT CHEMOTHERAPY; PHOSPHOLIPID-METABOLISM; MALIGNANCY MARKER; FAT RATIO; LESIONS; QUANTIFICATION; WATER;

D O I：

10.1186/bcr3132

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

An emerging clinical modality called proton magnetic resonance spectroscopy (H-1-MRS) enables the non-invasive in vivo assessment of tissue metabolism and is demonstrating applications in improving the specificity of MR breast lesion diagnosis and monitoring tumour responsiveness to neoadjuvant chemotherapies. Variations in the concentration of choline-based cellular metabolites, detectable with H-1-MRS, have shown an association with malignant transformation of tissue in in vivo and in vitro studies. H-1-MRS exists as an adjunct to the current routine clinical breast MR examination. This review serves as an introduction to the field of breast H-1-MRS, discusses modern high-field strength and quantitative approaches and technical considerations, and reviews the literature with respect to the application of H-1-MRS for breast cancer.

引用

页数：10

共 59 条

[1]

Aboagye EO, 1999, CANCER RES, V59, P80

[2]

Proton MR spectroscopy for monitoring early treatment response of breast cancer to neo-adjuvant chemotherapy [J].