Detection of choline signal in human breast lesions with chemical-shift imaging

被引:30
作者
Baek, Hyeon-Man [1 ]
Chen, Jeon-Hor [1 ,2 ]
Yu, Hon J. [1 ]
Mehta, Rita [3 ]
Nalcioglu, Orhan [1 ]
Su, Min-Ying [1 ]
机构
[1] Univ Calif Irvine, Tu & Yuen Ctr Funct Oncoimaging, Irvine, CA 92697 USA
[2] China Med Univ Hosp, Dept Radiol, Taichung, Taiwan
[3] Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA
关键词
breast tumor diagnosis; chemical-shift imaging; choline-containing compounds; dynamic contrast-enhanced; MRI; ROC analysis J. Magn. Reson;
D O I
10.1002/jmri.21309
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 [临床医学]; 100207 [影像医学与核医学]; 1009 [特种医学];
摘要
Purpose: To investigate the application of MR spectroscopy using chemical-shift imaging (CSI) for characterizing human breast lesions at 1.5T, and to evaluate the diagnostic performance using ROC (receiver operating characteristics) analysis. Materials and Methods: Thirty-six patients (35-73 years old, mean 52). with 27 malignant and 9 benign lesions, underwent anatomical imaging. dynamic contrast-enhanced MR imaging. and CSI. The ROC analysis was performed and the cutoff point yielding the highest accuracy was found to be a choline (Cho) signal-to-noise ratio (SNR) > 3.2. Results: The mean Cho SNR was 2.8 +/- 0.8 (range, 1.8 - 4.3) for the benign group and 5.9 +/- 3.4 (2.1-17.5) for the malignant group (P = 0.01). Based on the criterion of Cho SNR > 3.2 as malignant, CSI correctly diagnosed 22 of 27 malignant lesions and 7 of 9 benign lesions, resulting in a sensitivity of 8 1 %, specificity of 78%, and overall accuracy of 8 1 %. If the criterion was set higher at Cho SNR > 4.0 the specificity improved to 89% but sensitivity was lowered to 67%. Conclusion: The ROC analysis presented in this work could be used to set an objective diagnostic criterion depending on preferred emphasis on sensitivity or specificity.
引用
收藏
页码:1114 / 1121
页数:8
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