Interstitial cells of Cajal as pacemakers in the gastrointestinal tract

被引:445
作者
Sanders, KM [1 ]
Koh, SD [1 ]
Ward, SM [1 ]
机构
[1] Univ Nevada, Sch Med, Dept Physiol & Cell Biol, Reno, NV 89557 USA
关键词
smooth muscle; electrical rhythmicity; slow wave;
D O I
10.1146/annurev.physiol.68.040504.094718
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
In the gastrointestinal tract, phasic contractions are caused by electrical activity termed slow waves. Slow waves are generated and actively propagated by interstitial cells of Cajal (ICC). The initiation of pacemaker activity in the ICC is Caused by release of Ca2+ from inositol 1,4,5-trisphosphate (IP3) receptor-operated stores, uptake of Ca2+ into mitochondria, and the development of unitary currents. Summation of unitary currents causes depolarization and activation of a dihydropyridine-resistant Ca2+ conductance that entrains pacemaker activity in a network of ICC, resulting in the active propagation of slow waves. Slow wave frequency is regulated by a variety of physiological agonists and conditions, and shifts in pacemaker dominance can occur in response to both neural and nonneural inputs. Loss of ICC in many human motility disorders suggests exciting new hypotheses for the etiology of these disorders.
引用
收藏
页码:307 / 343
页数:37
相关论文
共 104 条
  • [1] PACEMAKER ACTIVITY RECORDED IN INTERSTITIAL-CELLS OF CAJAL OF THE GASTROINTESTINAL-TRACT
    BARAJASLOPEZ, C
    BEREZIN, I
    DANIEL, EE
    HUIZINGA, JD
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (04): : C830 - C835
  • [2] Pacing of interstitial cells of Cajal in the murine gastric antrum: neurally mediated and direct stimulation
    Beckett, EAH
    McGeough, CA
    Sanders, KM
    Ward, SM
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2003, 553 (02): : 545 - 559
  • [3] Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach
    Burns, AJ
    Lomax, AEJ
    Torihashi, S
    Sanders, KM
    Ward, SM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (21) : 12008 - 12013
  • [4] A clinical and biological overview of gastrointestinal stromal tumors
    Candelaria, M
    de la Garza, J
    Duenas-Gonzalez, A
    [J]. MEDICAL ONCOLOGY, 2005, 22 (01) : 1 - 10
  • [5] Proteins of interstitial cells of Cajal and intestinal smooth muscle, colocalized with caveolin-1
    Cho, WJ
    Daniel, EE
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2005, 288 (03): : G571 - G585
  • [6] CHRISTENSEN J, 1975, GASTROENTEROLOGY, V68, P601
  • [7] Role of caveolae and caveolins in health and disease
    Cohen, AW
    Hnasko, R
    Schubert, W
    Lisanti, MP
    [J]. PHYSIOLOGICAL REVIEWS, 2004, 84 (04) : 1341 - 1379
  • [8] CALCIUM CURRENT IN ISOLATED NEONATAL RAT VENTRICULAR MYOCYTES
    COHEN, NM
    LEDERER, WJ
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1987, 391 : 169 - 191
  • [9] Biology of gastrointestinal stromal tumors
    Corless, CL
    Fletcher, JA
    Heinrich, MC
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (18) : 3813 - 3825
  • [10] Electrical coupling between the myenteric interstitial cells of Cajal and adjacent muscle layers in the guinea-pig gastric antrum
    Cousins, HM
    Edwards, FR
    Hickey, H
    Hill, CE
    Hirst, GDS
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2003, 550 (03): : 829 - 844