Interstitial cells of Cajal as pacemakers in the gastrointestinal tract

被引:445
作者
Sanders, KM [1 ]
Koh, SD [1 ]
Ward, SM [1 ]
机构
[1] Univ Nevada, Sch Med, Dept Physiol & Cell Biol, Reno, NV 89557 USA
关键词
smooth muscle; electrical rhythmicity; slow wave;
D O I
10.1146/annurev.physiol.68.040504.094718
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
In the gastrointestinal tract, phasic contractions are caused by electrical activity termed slow waves. Slow waves are generated and actively propagated by interstitial cells of Cajal (ICC). The initiation of pacemaker activity in the ICC is Caused by release of Ca2+ from inositol 1,4,5-trisphosphate (IP3) receptor-operated stores, uptake of Ca2+ into mitochondria, and the development of unitary currents. Summation of unitary currents causes depolarization and activation of a dihydropyridine-resistant Ca2+ conductance that entrains pacemaker activity in a network of ICC, resulting in the active propagation of slow waves. Slow wave frequency is regulated by a variety of physiological agonists and conditions, and shifts in pacemaker dominance can occur in response to both neural and nonneural inputs. Loss of ICC in many human motility disorders suggests exciting new hypotheses for the etiology of these disorders.
引用
收藏
页码:307 / 343
页数:37
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