Acetylation and deacetylation of non-histone proteins

被引：1278

作者：

Glozak, MA ^{[1
]}

Sengupta, N ^{[1
]}

Zhang, XH ^{[1
]}

Seto, E ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA

来源：

GENE | 2005年 / 363卷

基金：

美国国家卫生研究院;

关键词：

HATs; HDACs; post-translational modification;

D O I：

10.1016/j.gene.2005.09.010

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Since the first report of p53 as a non-histone target of a historic acetyltransferase (HAT), there has been a rapid proliferation in the description of new non-histone targets of HATs. Of these, transcription factors comprise the largest class of new targets. The substrates for HATs extend to cytoskeletal proteins, molecular chaperones and nuclear import factors. Deacetylation of these non-histone proteins by historic deacetylases (HDACs) opens yet another exciting new field of discovery in the role of the dynamic acetylation and deacetylation on cellular function. This review will focus on these non-histone targets of HATs and HDACs and the consequences of their modification. (c) 2005 Elsevier B.V All rights reserved.

引用

页码：15 / 23

页数：9

共 93 条

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