New applications of bis(oxazoline) ligands in catalysis:: Asymmetric 1,2-and 1,4-addition of ZnR2 to carbonyl compounds

被引：97

作者：

Schinnerl, M ^{[1
]}

Seitz, M ^{[1
]}

Kaiser, A ^{[1
]}

Reiser, O ^{[1
]}

机构：

[1] Univ Regensburg, Inst Organ Chem, D-93053 Regensburg, Germany

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 26期

关键词：

D O I：

10.1021/ol016925g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The enantioselective addition of ZnR2 to aldehydes (1,2) and cyclic enones (1,4) was accomplished using bis(oxazolines) as chiral ligands. The requirement for hydroxymethylene side chains in the ligands strongly suggests that bimetallic catalysts are decisive for high enantiocontrol in these additions.

引用

页码：4259 / 4262

页数：4

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