Catalytic asymmetric ring opening of epoxides to chlorohydrins with mild chloride donors and enantiopure titanium complexes

被引:25
作者
Bruns, S [1 ]
Haufe, G [1 ]
机构
[1] Univ Munster, Inst Organ Chem, D-48149 Berlin, Germany
关键词
D O I
10.1016/S0957-4166(99)00141-X
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The ring opening of symmetric and racemic epoxides with dilithium tetrachlorocuprate or trimethylsilyl chloride in the presence of titanium (R,R)-(+)-TADDOLates or a titanium (R)-(+)-BINOL complex gave vicinal chlorohydrins or their TMS ethers with maximum 36% enantiomeric excess. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码:1563 / 1569
页数:7
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