In vivo GABA editing using a novel doubly selective multiple quantum filter

被引:50
作者
Shen, J
Rothman, DL
Brown, P
机构
[1] Nathan S Kline Inst Psychiat Res, Ctr Adv Brain Imaging, Orangeburg, NY 10962 USA
[2] NYU, Sch Med, Dept Radiol, New York, NY USA
[3] Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06520 USA
关键词
GABA; multiple quantum; DANTE pulse; quantitation; macromolecules;
D O I
10.1002/mrm.10104
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
A novel multiple quantum filtering method is proposed that uses a doubly selective pulse termed Delays Alternating with Nutations for Tailored Excitation (DANTE) for multiple quantum preparation. This method selectively prepares GABA-3 and GABA-4 into a multiple quantum state and suppresses all other resonances at 3.0 ppm in each single scan. Phantom tests demonstrated excellent GABA signal retention and complete suppression of overlapping metabolites. It is shown using numerical simulations that overlapping macromolecules are suppressed because the frequency of the first upfield 2pi rotation of the doubly selective DANTE pulse coincides with that of the macromolecules at 1.72 ppm. Excellent suppression of overlapping macromolecules was demonstrated in vivo. Using this method the concentration of GABA in the occipital lobe of healthy volunteers was measured to be 1.21 +/- 0.28 mumol/mL (mean +/- SD, N = 9). (C) 2002 Wiley-Liss, Inc.
引用
收藏
页码:447 / 454
页数:8
相关论文
共 39 条
[1]   Preliminary evidence of low cortical GABA levels in localized 1H-MR spectra of alcohol-dependent and hepatic encephalopathy patients [J].
Behar, KL ;
Rothman, DL ;
Petersen, KF ;
Hooten, M ;
Delaney, R ;
Petroff, OAC ;
Shulman, GI ;
Navarro, V ;
Petrakis, IL ;
Charney, DS ;
Krystal, JH .
AMERICAN JOURNAL OF PSYCHIATRY, 1999, 156 (06) :952-954
[2]   ANALYSIS OF MACROMOLECULE RESONANCES IN H-1-NMR SPECTRA OF HUMAN BRAIN [J].
BEHAR, KL ;
ROTHMAN, DL ;
SPENCER, DD ;
PETROFF, OAC .
MAGNETIC RESONANCE IN MEDICINE, 1994, 32 (03) :294-302
[3]   USE OF ROTATING-PHASE DANTE PULSES FOR INVIVO PROTON NMR SPECTRAL EDITING WITH A SINGLE IRRADIATION FACILITY [J].
BLONDET, P ;
ALBRAND, JP ;
VONKIENLIN, M ;
DECORPS, M ;
LAVANCHY, N .
JOURNAL OF MAGNETIC RESONANCE, 1987, 71 (02) :342-346
[4]   QUATERNIONS AS A PRACTICAL TOOL FOR THE EVALUATION OF COMPOSITE ROTATIONS [J].
BLUMICH, B ;
SPIESS, HW .
JOURNAL OF MAGNETIC RESONANCE, 1985, 61 (02) :356-362
[5]  
COOPER AJL, 1998, GLUTATHIONE NERVOUS, P91
[6]  
DEGRAAF RA, 2000, P 8 ANN M ISMRM DENV, P605
[7]   OPTIMIZATION OF SHAPED SELECTIVE PULSES FOR NMR USING A QUATERNION DESCRIPTION OF THEIR OVERALL PROPAGATORS [J].
EMSLEY, L ;
BODENHAUSEN, G .
JOURNAL OF MAGNETIC RESONANCE, 1992, 97 (01) :135-148
[8]   SELECTIVE EXCITATION AT 2 ARBITRARY FREQUENCIES - THE DOUBLE-DANTE SEQUENCE [J].
GEEN, H ;
WU, XL ;
XU, P ;
FRIEDRICH, J ;
FREEMAN, R .
JOURNAL OF MAGNETIC RESONANCE, 1989, 81 (03) :646-652
[9]   AUTOMATIC, LOCALIZED INVIVO ADJUSTMENT OF ALL 1ST-ORDER AND 2ND-ORDER SHIM COILS [J].
GRUETTER, R .
MAGNETIC RESONANCE IN MEDICINE, 1993, 29 (06) :804-811
[10]   THEORETICAL-ANALYSIS OF RELAXATION DURING SHAPED PULSES .1. THE EFFECTS OF SHORT T(1) AND T(2) [J].
HAJDUK, PJ ;
HORITA, DA ;
LERNER, LE .
JOURNAL OF MAGNETIC RESONANCE SERIES A, 1993, 103 (01) :40-52