The association between organochlorine and thyroid hormone levels in cord serum: A study from northern Thailand

被引:59
作者
Asawasinsopon, R
Prapamontol, T
Prakobvitayakit, O
Vaneesorn, Y
Mangklabruks, A
Hock, B
机构
[1] Chiang Mai Univ, Res Inst Hlth Sci, Pollut & Environm Hlth Res Program, Chiang Mai 50202, Thailand
[2] Chiang Mai Univ, Fac Sci, Environm Sci PhD Program, Chiang Mai 50200, Thailand
[3] Chiang Mai Univ, Fac Sci, Dept Biol, Chiang Mai 50200, Thailand
[4] Chiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, Thailand
[5] Chiang Mai Univ, Fac Sci, Dept Internal Med, Chiang Mai 50200, Thailand
[6] Tech Univ Munich, Dept Cell Biol, Ctr Life & Food Sci Weihenstephan, D-85350 Freising Weihenstephan, Germany
关键词
organochlorines; thyroid hormones; infants; endocrine disruption; persistent organic pollutants; prenatal exposure; DDT;
D O I
10.1016/j.envint.2006.01.001
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
It is now known that many organochlorines (OCs) act as endocrine disruptors, causing harmful effects on wildlife and humans. Several field and laboratory animal studies have reported that OCs cause adverse effects on thyroid hormone status. However, data regarding their effects on thyroid hormone status in humans are inconclusive. Because a developing fetus is especially sensitive to hormonal disruption by exposure to OCs, the adverse health effects on infants are of concern. The present study aimed to investigate the association between OC levels in maternal and cord serum, and the association between OC and thyroid hormone levels in cord serum. The study was performed with 39 mother-infant pairs from Mae Rim District of Chiang Mai Province, northern Thailand, who had normal delivery and full term gestation. Maternal blood was collected for measuring OCs and total lipids. Umbilical cord blood was collected for measuring OCs, total lipids, and thyroid hormones, including total thyroxine (TT4), free thyroxine (FT4), and thyroid stimulating hormone (TSH). 1,1-dichloro-2,2-di(4-chlorophenyl)ethylene (p,p'-DDE) had the highest level in all serum samples with a geometric mean of 1191 ng/g lipids in maternal serum and 742 ng/g lipids in cord serum. The second highest level was that for 1,1,1-tiichloro-2,2-di(4-chlorophenyl)ethane (p,p'-DDT), followed by 1,1-dichloro-2,2-di(4-chlorophenyl)ethane (p,p'-DDD). Levels of p,p'-DDE,p,p'-DDT,p,p'-DDD, and dieldrin in maternal serum were positively associated with levels in cord serum (r=0.86, 0.77, 0.66, and 0.60, respectively; P < 0.001). The important findings were that cord serum TT4 levels were negatively associated with cord serum levels of p,p'-DDE (r=-0.37, P=0.024), p,p'-DDT.3 (r=-0.33, P=0.048), and 1,1-dichloro-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethylene (o,p'-DDE) (r=-0.76, P=0.019). These results therefore suggest that exposure to DDT and its metabolites during fetal development may cause some effects on thyroid hormonal status in infants. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:554 / 559
页数:6
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