Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element

被引:44
作者
Hogan, MR [1 ]
Cockram, GRP [1 ]
Lu, R [1 ]
机构
[1] Univ Guelph, Dept Mol & Cellular Biol, Guelph, ON N1G 2W1, Canada
来源
FEBS LETTERS | 2006年 / 580卷 / 01期
基金
加拿大自然科学与工程研究理事会;
关键词
activating transcription factor 4; cyclic AMP response element; leucine zipper; mitogen-activated protein/extracellular signal; regulated kinase kinase; protein-protein interaction; Zhangfei;
D O I
10.1016/j.febslet.2005.11.046
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Zhangfei (ZF) is a basic region-leucine zipper protein that has been implicated in herpesvirus infection cycle and related cellular processes. Here we show both in vivo and in vitro data demonstrating that ZF is a novel cellular binding partner of activating transcription factor 4 (ATF4) (or CREB2). We found that ZF competed with ATF4 to form ATF4-ZF heterodimeric complexes through the bZIP regions. ZF enhanced ATF4 binding to the cAMP response element (CRE), and augmented activation of a CRE reporter by ATF4, in response to MEK1 activation. These results suggest an important role of ZF in the MEK1-ATF4 signaling pathway. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:58 / 62
页数:5
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