Role of Exercise in the Activation of Brown Adipose Tissue

被引：94

作者：

Sanchez-Delgado, Guillermo ^{[1
]}

Martinez-Tellez, Borja ^{[1
]}

Olza, Josune ^{[2
]}

Aguilera, Concepcion M. ^{[2
]}

Gil, Angel ^{[2
]}

Ruiz, Jonatan R. ^{[1
]}

机构：

[1] Univ Granada, Fac Sport Sci, Dept Phys Educ & Sport, PROFITH PROmoting FITness & Hlth Phys Activ Res G, ES-18071 Granada, Spain

[2] Univ Granada, Ctr Biomed Res, Inst Nutr & Food Technol, Dept Biochem & Mol Biol 2, ES-18071 Granada, Spain

来源：

ANNALS OF NUTRITION AND METABOLISM | 2015年 / 67卷 / 01期

关键词：

Brown adipose tissue; BRITE adipose tissue; Exercise; Obesity; Physical activity; Thermogenesis; MESSENGER-RNA EXPRESSION; GROWTH-FACTOR; 21; RECEPTOR-GAMMA; BODY-WEIGHT; WHITE FAT; GLUCOSE-HOMEOSTASIS; COLD-EXPOSURE; ADULT HUMANS; FGF21; LEVELS; MUSCLE;

D O I：

10.1159/000437173

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background: The energy-burning capacity of brown adipose tissue (BAT) makes it an attractive target for use in anti-obesity therapies. Moreover, due to its ability to oxidize glucose and lipids, BAT activation has been considered a potential therapy to combat type 2 diabetes and atherogenesis. Summary: BAT is mainly regulated by the sympathetic nervous system (SNS); yet, recent findings have shown a group of novel activators that act independently of the stimulation of the SNS such as cardiac natriuretic peptides, irisin, interleukin-6, beta-aminoisobutyric acid and fibroblast growth factor 21 that could influence BAT metabolism. Several strategies are being examined to activate and recruit BAT with no side effects. In this review, we postulate that exercise might activate and recruit human BAT through the activation of SNS, heart and skeletal muscle. Key Messages: Epidemiological and well-designed exercise-based randomized controlled studies are needed to clarify if exercise is able to activate BAT in humans. (C) 2015 S. Karger AG, Basel

引用

页码：21 / 32

页数：12

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