Nanomedicine-Challenge and Perspectives

被引：986

作者：

Riehemann, Kristina ^{[1
,2
]}

Schneider, Stefan W. ^{[3
]}

Luger, Thomas A. ^{[4
]}

Godin, Biana ^{[5
]}

Ferrari, Mauro ^{[5
]}

Fuchs, Harald ^{[1
,2
]}

机构：

[1] Univ Munster, Ctr Nanotechnol, D-48149 Munster, Germany

[2] Univ Munster, Inst Phys, D-48149 Munster, Germany

[3] Heidelberg Univ, Univ Med Ctr Mannheim, Dept Dermatol, D-68135 Mannheim, Germany

[4] Klin & Polyklin Hautkrankheiten, D-48149 Munster, Germany

[5] Univ Texas Hlth Sci Ctr Houston, Dept Biomed Engn, Div Nanomed, Houston, TX 77030 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 05期

关键词：

nanoprobes; nanotechnology; personalized medicine; theranostics; PEGYLATED LIPOSOMAL DOXORUBICIN; ACCELERATED BLOOD CLEARANCE; DIGITAL HOLOGRAPHIC MICROSCOPY; ALBUMIN-BOUND PACLITAXEL; IN-VIVO; DRUG-DELIVERY; ANTIBODY ARRAYS; MASS-SPECTROMETRY; MAGNETIC NANOPARTICLES; NANOCRYSTALLINE SILVER;

D O I：

10.1002/anie.200802585

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The application of nanotechnology concepts to medicine joins two large cross-disciplinary fields with an unprecedented societal and economical potential arising from the natural combination of specific achievements in the respective fields. The common basis evolves from the molecular-scale properties relevant to the two fields. Local probes and molecular imaging techniques allow surface and interface properties to be characterized on a nanometer scale at predefined locations, while chemical approaches offer the opportunity to elaborate and address surfaces, for example, for targeted drug delivery, enhanced biocompatibility, and neuroprosthetic purposes. However, concerns arise in this cross-disciplinary area about toxicological aspects and ethical implications. This Review gives an overview of selected recent developments and applications of nanomedicine. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：872 / 897

页数：26

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