Glutathione potentiates cGMP synthesis induced by the two phenylfuroxancarbonitrile isomers in RFL-6 cells.

被引：7

作者：

DiStilo, A

Cena, C

Gasco, AM

Gasco, A

Ghigo, D

Bosia, A

机构：

[1] UNIV TURIN,DIPARTIMENTO SCI & TECNOL FARMACO,I-10125 TURIN,ITALY

[2] UNIV TURIN,DIPARTIMENTO GENET BIOL & CHIM MED,I-10126 TURIN,ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 21期

关键词：

D O I：

10.1016/0960-894X(96)00479-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The cellular mechanism of bioactivation underlying guanylate cyclase activation by the pair of phenylfuroxancarbonitrile isomers 2a, b was investigated. In cultured rat lung fibroblast (RFL-6 cells) it was principally dependent on intracellular thiols. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2607 / 2612

页数：6

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