Serotonin transporter gene not associated with psychotic symptomatology of mood disorders

被引：19

作者：

Serretti, A ^{[1
]}

Lattuada, E ^{[1
]}

Catalano, M ^{[1
]}

Smeraldi, E ^{[1
]}

机构：

[1] Univ Milan, Sch Med, Dept Neurosci, Ist Sci H San Raffaele, I-20127 Milan, Italy

来源：

PSYCHIATRY RESEARCH | 1999年 / 86卷 / 01期

关键词：

serotonin; serotonin receptors; bipolar disorder; depressive disorder; phenotype;

D O I：

10.1016/S0165-1781(99)00021-9

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

A functional polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) has been recently reported to be associated with mood disorders. In the present study we investigated the possible influence of 5-HTTLPR on the symptomatology of mood disorders. Two hundred and thirty inpatients affected by mood disorders (160 bipolar and 70 major depressive disorder) were assessed by the Operational Criteria checklist for psychotic illness (OPCRIT) and were also typed for the 5-HTTLPR variants using PCR techniques. Mania, Depression, Delusion and Disorganization were the four symptomatologic factors used as phenotype definition. 5-HTTLPR variants were not associated with these symptomatologic factors, and consideration of possible stratification effects, such as sex, age of onset and polarity, did not reveal any association either. The serotonin transporter gene does not, therefore, appear to be associated with the symptomatology of mood disorders. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：59 / 65

页数：7

共 47 条

[1]

[Anonymous], 1990, BMDP STAT SOFTWARE M

[2] The serotonin transporter gene and peer-rated neuroticism [J].

Ball, D ;

Hill, L ;

Freeman, B ;

Eley, TC ;

Strelau, J ;

Riemann, R ;

Spinath, FM ;

Angleitner, A ;

Plomin, R .

NEUROREPORT, 1997, 8 (05) :1301-1304

[3]

BARBUJANI G, 1991, HUM BIOL, V63, P253

[4] Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder [J].

Battersby, S ;

Ogilvie, AD ;

Smith, CAD ;

Blackwood, DHR ;

Muir, WJ ;

Quinn, JP ;

Fink, G ;

Goodwin, GM ;

Harmar, AJ .

PSYCHIATRIC GENETICS, 1996, 6 (04) :177-181

[5] SEROTONERGIC MECHANISMS IN PSYCHIATRIC-DISORDERS - NEW RESEARCH TOOLS, NEW IDEAS [J].

BENKELFAT, C .

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1993, 8 :53-56

[6] The efficacy of 2 different dosages of methylphenidate in treating adults with attention-deficit hyperactivity disorder [J].

Bouffard, R ;

Hechtman, L ;

Minde, K ;

Iaboni-Kassab, F .

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2003, 48 (08) :546-554

[7]

Bradley CC, 1997, J NEUROCHEM, V69, P1356

[8] Mapping genes for human personality [J].

Cloninger, CR ;

Adolfsson, R ;

Svrakic, NM .

NATURE GENETICS, 1996, 12 (01) :3-4

[9] TURNING-POINT IN THE DESIGN OF LINKAGE STUDIES OF SCHIZOPHRENIA [J].

CLONINGER, CR .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1994, 54 (02) :83-92

[10]

Cohen J., 1988, Statistical Power Analysis for the Behavioral Sciences, V2

← 1 2 3 4 5 →