DNA nanostructure serum stability: greater than the sum of its parts

被引：204

作者：

Conway, Justin W. ^{[1
]}

McLaughlin, Christopher K. ^{[1
]}

Castor, Katherine J. ^{[1
]}

Sleiman, Hanadi ^{[1
]}

机构：

[1] Dept Chem, Montreal, PQ H3A 0B8, Canada

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 12期

基金：

加拿大自然科学与工程研究理事会;

关键词：

OLIGONUCLEOTIDES; NANOPARTICLES;

D O I：

10.1039/c2cc37556g

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Simple chemical modifications to oligonucleotide ends with hexaethylene glycol and hexanediol are shown to significantly increase nuclease resistance under serum conditions. The modified oligonucleotides were used to construct DNA prismatic cages in a single step and in quantitative yield. These cages further stabilize their strands towards nucleases, with lifetimes of 62 hours in serum. The cages contain a large number of single-stranded regions for functionalization, illustrating their versatility for biological applications.

引用

收藏

页码：1172 / 1174

页数：3

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