A retrospective study of Creutzfeldt-Jakob disease in Belgium

被引：15

作者：

Pals, P ^{[1
]}

Everbroeck, BV ^{[1
]}

Sciot, R ^{[1
]}

Godfraind, C ^{[1
]}

Robberecht, W ^{[1
]}

Dom, R ^{[1
]}

Laterre, C ^{[1
]}

Martin, JJ ^{[1
]}

Cras, P ^{[1
]}

机构：

[1] Univ Antwerp, Neurobiol Lab, Born Bunge Fdn, B-2610 Wilrijk, Belgium

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 1999年 / 15卷 / 06期

关键词：

Creutzfeldt-Jakob disease; dementia; EEG; epidemiology; myoclonus; prion;

D O I：

10.1023/A:1007581313067

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Using data from Belgian neuropathological archives, completed with the results of a comprehensive study of available medical records, we found 100 patients who fulfilled diagnostic criteria for probable or definite Creutzfeldt-Jakob disease (CJD). Mean age at death was 63 years. The median disease duration was 9 months. Progressive mental deterioration was present in all cases, whereas signs of cerebellar dysfunction and myoclonus were found in approximately 80% of the patients. In 50% of the population, the EEG revealed characteristic abnormalities. Ninety-six patients suffered from the sporadic type of CJD, while 4 suffered from a hereditary form. In our series, we could find no evidence for the new variant, neither for an iatrogenic cause.

引用

页码：517 / 519

页数：3

共 14 条

[1] HUMAN SPONGIFORM ENCEPHALOPATHY - THE NATIONAL-INSTITUTES-OF-HEALTH SERIES OF 300 CASES OF EXPERIMENTALLY TRANSMITTED DISEASE [J].

BROWN, P ;

GIBBS, CJ ;

RODGERSJOHNSON, P ;

ASHER, DM ;

SULIMA, MP ;

BACOTE, A ;

GOLDFARB, LG ;

GAJDUSEK, DC .

ANNALS OF NEUROLOGY, 1994, 35 (05) :513-529

[2] CREUTZFELDT-JAKOB DISEASE IN FRANCE .1. RETROSPECTIVE STUDY OF THE PARIS AREA DURING THE 10-YEAR PERIOD 1968-1977 [J].

BROWN, P ;

CATHALA, F .

ANNALS OF NEUROLOGY, 1979, 5 (02) :189-192

[3] New variant of Creutzfeldt-Jakob disease in a 26-year-old French man [J].

Chazot, G ;

Broussolle, E ;

Lapras, C ;

Blattler, T ;

Aguzzi, A ;

Kopp, N .

LANCET, 1996, 347 (9009) :1181-1181

[4] Bovine spongiform encephalopathy and a new variant of Creutzfeldt-Jakob disease [J].

Epstein, LG ;

Brown, P .

NEUROLOGY, 1997, 48 (03) :569-571

[5] MAGNETIC-RESONANCE-IMAGING IN CREUTZFELDT-JAKOB DISEASE [J].

ESMONDE, TFG ;

WILL, RG .

ANNALS OF NEUROLOGY, 1992, 31 (02) :230-231

[6] Transmissible spongiform encephalopathies [J].

Haywood, AM .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (25) :1821-1828

[7] Diagnostic criteria for sporadic Creutzfeldt-Jakob disease [J].

Kretzschmar, HA ;

Ironside, JW ;

DeArmond, SJ ;

Tateishi, J .

ARCHIVES OF NEUROLOGY, 1996, 53 (09) :913-920

[8] CREUTZFELDT-JAKOB DISEASE - PATTERNS OF WORLDWIDE OCCURRENCE AND THE SIGNIFICANCE OF FAMILIAL AND SPORADIC CLUSTERING [J].

MASTERS, CL ;

HARRIS, JO ;

GAJDUSEK, DC ;

GIBBS, CJ ;

BERNOULLI, C ;

ASHER, DM .

ANNALS OF NEUROLOGY, 1979, 5 (02) :177-188

[9] A RETROSPECTIVE STUDY OF CREUTZFELDT-JAKOB DISEASE IN ITALY (1972-1986) [J].

MASULLO, C ;

POCCHIARI, M ;

NERI, G ;

CASACCIA, P ;

IAVARONE, A ;

LADOGANA, A ;

MACCHI, G .

EUROPEAN JOURNAL OF EPIDEMIOLOGY, 1988, 4 (04) :482-487

[10] Accuracy and reliability of periodic sharp wave complexes in Creutzfeldt-Jakob disease [J].

Steinhoff, BJ ;

Racker, S ;

Herrendorf, G ;

Poser, S ;

Grosche, S ;

Zerr, I ;

Kretzschmar, H ;

Weber, T .

ARCHIVES OF NEUROLOGY, 1996, 53 (02) :162-166

← 1 2 →