A retrospective study of Creutzfeldt-Jakob disease in Belgium

被引：15

作者：

Pals, P ^{[1
]}

Everbroeck, BV ^{[1
]}

Sciot, R ^{[1
]}

Godfraind, C ^{[1
]}

Robberecht, W ^{[1
]}

Dom, R ^{[1
]}

Laterre, C ^{[1
]}

Martin, JJ ^{[1
]}

Cras, P ^{[1
]}

机构：

[1] Univ Antwerp, Neurobiol Lab, Born Bunge Fdn, B-2610 Wilrijk, Belgium

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 1999年 / 15卷 / 06期

关键词：

Creutzfeldt-Jakob disease; dementia; EEG; epidemiology; myoclonus; prion;

D O I：

10.1023/A:1007581313067

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Using data from Belgian neuropathological archives, completed with the results of a comprehensive study of available medical records, we found 100 patients who fulfilled diagnostic criteria for probable or definite Creutzfeldt-Jakob disease (CJD). Mean age at death was 63 years. The median disease duration was 9 months. Progressive mental deterioration was present in all cases, whereas signs of cerebellar dysfunction and myoclonus were found in approximately 80% of the patients. In 50% of the population, the EEG revealed characteristic abnormalities. Ninety-six patients suffered from the sporadic type of CJD, while 4 suffered from a hereditary form. In our series, we could find no evidence for the new variant, neither for an iatrogenic cause.

引用

页码：517 / 519

页数：3

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