A statistical multiprobe model for analyzing cis and trans genes in genetical genomics experiments with short-oligonucleotide arrays

被引：28

作者：

Alberts, R

Terpstra, P

Bystrykh, LV

de Haan, G

Jansen, RC

机构：

[1] Univ Groningen, Groningen Bioinformat Ctr, Groningen Biomol Sci & Biotechnol Inst, NL-9751 NN Haren, Netherlands

[2] Univ Groningen, Ctr Med, Sect Stem Cell Biol, Dept Cell Biol, NL-9713 AV Groningen, Netherlands

来源：

GENETICS | 2005年 / 171卷 / 03期

关键词：

D O I：

10.1534/genetics.105.045930

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Short-oligonucleotide arrays typically contain multiple probes per gene. In genetical genomics applications a statistical model for the individual probe signals can help in separating "true" differential mRNA expression from "ghost" effects caused by polymorphisms, misdesigned probes, and batch effects. It can also help in detecting alternative splicing, start, or termination.

引用

页码：1437 / 1439

页数：3

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