An ultrasensitive electrochemical impedance sensor for a special BRCA1 breast cancer gene sequence based on lambda exonuclease assisted target recycling amplification

被引:64
作者
Xu, Huifeng [1 ,2 ]
Wang, Lili [1 ,2 ]
Ye, Hongzhi [1 ]
Yu, Lishuang [1 ]
Zhu, Xi [2 ]
Lin, Zhenyu [2 ]
Wu, Guangwen [1 ]
Li, Xihai [1 ]
Liu, Xianxiang [1 ]
Chen, Guonan [2 ]
机构
[1] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou, Fujian, Peoples R China
[2] Fuzhou Univ, Key Lab Anal & Detect Food Safety, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Minist Educ,Dept Chem, Fuzhou 350002, Fujian, Peoples R China
关键词
DNA DETECTION; BIOSENSOR;
D O I
10.1039/c2cc31588b
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A label-free, target recycling electrochemical impedance spectroscopy (EIS) DNA sensor has been developed for detection of a model related to the BRCA1 breast cancer gene with a detection limit of 0.05 nM.
引用
收藏
页码:6390 / 6392
页数:3
相关论文
共 35 条
[1]   Novel genomic rearrangements in the BRCA1 gene detected in greek breast/ovarian cancer patients [J].
Armaou, Sophia ;
Konstantopoulou, Irene ;
Anagnostopoulos, Theodore ;
Razis, Evangelia ;
Boukovinas, Ioannis ;
Xenidis, Nikolaos ;
Fountzilas, George ;
Yannoukakos, Drakoulis .
EUROPEAN JOURNAL OF CANCER, 2007, 43 (02) :443-453
[2]   Electrochemical genosensors for biomedical applications based on gold nanoparticles [J].
Castaneda, M. T. ;
Merkoci, A. ;
Pumera, M. ;
Alegret, S. .
BIOSENSORS & BIOELECTRONICS, 2007, 22 (9-10) :1961-1967
[3]   An ultrahighly sensitive and selective electrochemical DNA sensor via nicking endonuclease assisted current change amplification [J].
Chen, Jinghua ;
Zhang, Jing ;
Li, Juan ;
Fu, Fengfu ;
Yang, Huang-Hao ;
Chen, Guonan .
CHEMICAL COMMUNICATIONS, 2010, 46 (32) :5939-5941
[4]   Electrochemical detection of mismatched DNA using a MutS probe [J].
Cho, Minseon ;
Lee, Sohyun ;
Han, Se-Young ;
Park, Jin-Young ;
Rahman, Md Aminur ;
Shim, Yoon-Bo ;
Ban, Changill .
NUCLEIC ACIDS RESEARCH, 2006, 34 (10)
[5]   DNA detection using enzymatic signal production and SERS [J].
Dougan, Jennifer A. ;
MacRae, Douglas ;
Graham, Duncan ;
Faulds, Karen .
CHEMICAL COMMUNICATIONS, 2011, 47 (16) :4649-4651
[6]   Electrochemical DNA sensors [J].
Drummond, TG ;
Hill, MG ;
Barton, JK .
NATURE BIOTECHNOLOGY, 2003, 21 (10) :1192-1199
[7]   Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations [J].
Fackenthal, James D. ;
Olopade, Olufunmilayo I. .
NATURE REVIEWS CANCER, 2007, 7 (12) :937-948
[8]   Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA [J].
Fan, CH ;
Plaxco, KW ;
Heeger, AJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (16) :9134-9137
[9]   DNAzyme Molecular Beacon Probes for Target-Induced Signal-Amplifying Colorimetric Detection of Nucleic Acids [J].
Fu, Rongzhan ;
Li, Taihua ;
Lee, Soo Suk ;
Park, Hyun Gyu .
ANALYTICAL CHEMISTRY, 2011, 83 (02) :494-500
[10]   Optical sensors based on hybrid DNA/conjugated polymer complexes [J].
Ho, HA ;
Béra-Abérem, M ;
Leclerc, M .
CHEMISTRY-A EUROPEAN JOURNAL, 2005, 11 (06) :1718-1724