B-cell activating factor targeted therapy and lupus

被引：26

作者：

Boneparth, Alexis ^{[2
]}

Davidson, Anne ^{[1
]}

机构：

[1] Feinstein Inst Med Res, Ctr Autoimmun & Musculoskeletal Dis, Manhasset, NY 11030 USA

[2] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10461 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2012年 / 14卷

关键词：

PRIMARY SJOGRENS-SYNDROME; NECROSIS-FACTOR FAMILY; LYMPHOCYTE STIMULATOR; T-CELLS; TRANSMEMBRANE ACTIVATOR; MONOCLONAL-ANTIBODY; AUTOIMMUNE-DISEASE; DEPENDENT MANNER; DEFICIENT MICE; CUTTING EDGE;

D O I：

10.1186/ar3920

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

B-cell activating factor (BAFF), a member of the family of TNF-like cytokines, supports the survival and differentiation of B cells. The successful development of belimumab, a human antibody targeting soluble BAFF, has marked an important milestone in the development of biologic therapy for treatment of systemic lupus erythematosus (SLE), although much remains unknown regarding the clinical utility of BAFF inhibition in SLE and other autoimmune diseases. In the present review, we provide an overview of the knowledge concerning BAFF's role in murine and human B-cell development and maturation, as well as the clinical and mechanistic effects of BAFF inhibition in human SLE.

引用

页数：8

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