The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus

被引：200

作者：

Cancro, Michael P. ^{[1
]}

D'Cruz, David P. ^{[2
]}

Khamashta, Munther A. ^{[2
]}

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[2] Kings Coll London, Sch Med, Lupus Res Unit, Rayne Inst,St Thomas Hosp, London, England

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2009年 / 119卷 / 05期

关键词：

NECROSIS-FACTOR FAMILY; HUMAN MONOCLONAL-ANTIBODY; CELL MATURATION ANTIGEN; APRIL-DEFICIENT MICE; FACTOR-KAPPA-B; DISEASE-ACTIVITY; BAFF-R; AUTOIMMUNE-DISEASE; CUTTING EDGE; TNF RECEPTOR;

D O I：

10.1172/JCI38010

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a soluble ligand of the TNF cytokine family, is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producting B cells. High levels of BLyS may relax B cell selection and contribute to autoantibody production, exacerbating the SLE disease state. This review discusses the mechanism of BLyS action on B cells, its role in SLE, and specific targeting of BLyS in the treatment of SLE.

引用

页码：1066 / 1073

页数：8

共 113 条

[1] Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation [J].

Allman, D ;

Lindsley, RC ;

DeMuth, W ;

Rudd, K ;

Shinton, SA ;

Hardy, RR .

JOURNAL OF IMMUNOLOGY, 2001, 167 (12) :6834-6840

[2]

ALLMAN DM, 1993, J IMMUNOL, V151, P4431

[3] Enforced bcl-xL gene expression restored splenic B lymphocyte development in BAFF-R mutant mice [J].

Amanna, IJ ;

Dingwall, JP ;

Hayes, CE .

JOURNAL OF IMMUNOLOGY, 2003, 170 (09) :4593-4600

[4] Development of autoantibodies before the clinical onset of systemic lupus erythematosus [J].

Arbuckle, MR ;

McClain, MT ;

Rubertone, MV ;

Scofield, RH ;

Dennis, GJ ;

James, JA ;

Harley, JB .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (16) :1526-1533

[5]

Bae SC, 1998, ARTHRITIS RHEUM-US, V41, P2091, DOI 10.1002/1529-0131(199812)41:12<2091::AID-ART2>3.3.CO

[6]

2-4

[7] Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator [J].

Baker, KP ;

Edwards, BM ;

Main, SH ;

Choi, GH ;

Wager, RE ;

Halpern, WG ;

Lappin, PB ;

Riccobene, T ;

Abramian, D ;

Sekut, L ;

Sturm, B ;

Poortman, C ;

Minter, RR ;

Dobson, CL ;

Williams, E ;

Carmen, S ;

Smith, R ;

Roschke, V ;

Hilbert, DM ;

Vaughan, TJ ;

Albert, VR .

ARTHRITIS AND RHEUMATISM, 2003, 48 (11) :3253-3265

[8] APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells [J].

Belnoue, Elodie ;

Pihlgren, Maria ;

McGaha, Tracy L. ;

Tougne, Chantal ;

Rochat, Anne-Francoise ;

Bossen, Claudia ;

Schneider, Pascal ;

Huard, Bertrand ;

Lambert, Paul-Henri ;

Siegrist, Claire-Anne .

BLOOD, 2008, 111 (05) :2755-2764

[9] Cutting edge: The dependence of plasma cells and independence of memory B cells on BAFF and APRIL [J].

Benson, Micah J. ;

Dillon, Stacey R. ;

Castigli, Emanuela ;

Geha, Raif S. ;

Xu, Shengli ;

Lam, Konk-Peng ;

Noelle, Randolph J. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (06) :3655-3659

[10] The multifaceted roles of TRAFS in the regulation of B-cell function [J].

Bishop, GA .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (10) :775-786

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