The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus

被引：200

作者：

Cancro, Michael P. ^{[1
]}

D'Cruz, David P. ^{[2
]}

Khamashta, Munther A. ^{[2
]}

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[2] Kings Coll London, Sch Med, Lupus Res Unit, Rayne Inst,St Thomas Hosp, London, England

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2009年 / 119卷 / 05期

关键词：

NECROSIS-FACTOR FAMILY; HUMAN MONOCLONAL-ANTIBODY; CELL MATURATION ANTIGEN; APRIL-DEFICIENT MICE; FACTOR-KAPPA-B; DISEASE-ACTIVITY; BAFF-R; AUTOIMMUNE-DISEASE; CUTTING EDGE; TNF RECEPTOR;

D O I：

10.1172/JCI38010

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a soluble ligand of the TNF cytokine family, is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producting B cells. High levels of BLyS may relax B cell selection and contribute to autoantibody production, exacerbating the SLE disease state. This review discusses the mechanism of BLyS action on B cells, its role in SLE, and specific targeting of BLyS in the treatment of SLE.

引用

页码：1066 / 1073

页数：8

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