Evolutionary dynamics and emergence of panzootic H5N1 influenza viruses
被引:139
作者:
Vijaykrishna, Dhanasekaran
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机构:
Univ Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Shantou Univ, Int Inst Infect & Immun, Coll Med, Shantou, Guangdong, Peoples R ChinaUniv Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Vijaykrishna, Dhanasekaran
[1
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Bahl, Justin
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机构:
Univ Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Shantou Univ, Int Inst Infect & Immun, Coll Med, Shantou, Guangdong, Peoples R ChinaUniv Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Bahl, Justin
[1
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Riley, Steven
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机构:
Univ Hong Kong, Dept Commun Med, Pokfulam, Hong Kong, Peoples R China
Univ Hong Kong, Sch Publ Hlth, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Riley, Steven
[3
,4
]
Duan, Lian
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机构:
Univ Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Shantou Univ, Int Inst Infect & Immun, Coll Med, Shantou, Guangdong, Peoples R ChinaUniv Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Duan, Lian
[1
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Zhang, Jin Xia
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机构:
Univ Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Shantou Univ, Int Inst Infect & Immun, Coll Med, Shantou, Guangdong, Peoples R ChinaUniv Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Zhang, Jin Xia
[1
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Chen, Honglin
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机构:
Univ Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Shantou Univ, Int Inst Infect & Immun, Coll Med, Shantou, Guangdong, Peoples R ChinaUniv Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Chen, Honglin
[1
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Peiris, J. S. Malik
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Univ Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Peiris, J. S. Malik
[1
]
Smith, Gavin J. D.
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机构:
Univ Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Shantou Univ, Int Inst Infect & Immun, Coll Med, Shantou, Guangdong, Peoples R ChinaUniv Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Smith, Gavin J. D.
[1
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Guan, Yi
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机构:
Univ Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Shantou Univ, Int Inst Infect & Immun, Coll Med, Shantou, Guangdong, Peoples R ChinaUniv Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
Guan, Yi
[1
,2
]
机构:
[1] Univ Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
[2] Shantou Univ, Int Inst Infect & Immun, Coll Med, Shantou, Guangdong, Peoples R China
[3] Univ Hong Kong, Dept Commun Med, Pokfulam, Hong Kong, Peoples R China
[4] Univ Hong Kong, Sch Publ Hlth, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
The highly pathogenic avian influenza (HPAI) H5N1 virus lineage has undergone extensive genetic reassortment with viruses from different sources to produce numerous H5N1 genotypes, and also developed into multiple genetically distinct sublineages in China. From there, the virus has spread to over 60 countries. The ecological success of this virus in diverse species of both poultry and wild birds with frequent introduction to humans suggests that it is a likely source of the next human pandemic. Therefore, the evolutionary and ecological characteristics of its emergence from wild birds into poultry are of considerable interest. Here, we apply the latest analytical techniques to infer the early evolutionary dynamics of H5N1 virus in the population from which it emerged (wild birds and domestic poultry). By estimating the time of most recent common ancestors of each gene segment, we show that the H5N1 prototype virus was likely introduced from wild birds into poultry as a non-reassortant low pathogenic avian influenza H5N1 virus and was not generated by reassortment in poultry. In contrast, more recent H5N1 genotypes were generated locally in aquatic poultry after the prototype virus (A/goose/Guangdong/1/96) introduction occurred, i.e., they were not a result of additional emergence from wild birds. We show that the H5N1 virus was introduced into Indonesia and Vietnam 3-6 months prior to detection of the first outbreaks in those countries. Population dynamics analyses revealed a rapid increase in the genetic diversity of A/goose/Guangdong/1/96 lineage viruses from mid-1999 to early 2000. Our results suggest that the transmission of reassortant viruses through the mixed poultry population in farms and markets in China has selected HPAI H5N1 viruses that are well adapted to multiple hosts and reduced the interspecies transmission barrier of those viruses.
机构:
Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R ChinaShantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Chen, H
Smith, GJD
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Smith, GJD
Zhang, SY
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Zhang, SY
Qin, K
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Qin, K
Wang, J
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Wang, J
Li, KS
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Li, KS
Webster, RG
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Webster, RG
Peiris, JSM
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Peiris, JSM
Guan, Y
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
机构:
Penn State Univ, Dept Biol, Ctr Infect Dis Dynam, University Pk, PA 16802 USAPenn State Univ, Dept Biol, Ctr Infect Dis Dynam, University Pk, PA 16802 USA
Chen, Rubing
Holmes, Edward C.
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机构:Penn State Univ, Dept Biol, Ctr Infect Dis Dynam, University Pk, PA 16802 USA
机构:
Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R ChinaShantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Chen, H
Smith, GJD
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Smith, GJD
Zhang, SY
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Zhang, SY
Qin, K
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Qin, K
Wang, J
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Wang, J
Li, KS
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Li, KS
Webster, RG
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Webster, RG
Peiris, JSM
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
Peiris, JSM
Guan, Y
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机构:Shantou Univ Med Coll, Joint Influenza Res Ctr SUMC & HKU, Shantou 515031, Peoples R China
机构:
Penn State Univ, Dept Biol, Ctr Infect Dis Dynam, University Pk, PA 16802 USAPenn State Univ, Dept Biol, Ctr Infect Dis Dynam, University Pk, PA 16802 USA
Chen, Rubing
Holmes, Edward C.
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机构:Penn State Univ, Dept Biol, Ctr Infect Dis Dynam, University Pk, PA 16802 USA