Early neocortical regionalization in the absence of thalamic innervation

被引:260
作者
Miyashita-Lin, EM
Hevner, R
Wassarman, KM
Martinez, S
Rubenstein, JLR [1 ]
机构
[1] Univ Calif San Francisco, Sch Med, Dept Psychiat, Nina Ireland Lab Dev Neurobiol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Sch Med, Dept Anat, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Sch Med, Program Dev Biol, San Francisco, CA 94143 USA
[4] Univ Miguel Hernandez, Univ Murcia, Inst Neurosci, Fac Med,Dept Morphol Sci, Alicante, Spain
关键词
D O I
10.1126/science.285.5429.906
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
There is a Long-standing controversy regarding the mechanisms that generate the functional subdivisions of the cerebral neocortex. One model proposes that thalamic axonal input specifies these subdivisions; the competing model postulates that patterning mechanisms intrinsic to the dorsal telencephalon generate neocortical regions. Gbx-2 mutant mice, whose thalamic differentiation is disrupted, were investigated. Despite the Lack of cortical innervation by thalamic axons, neocortical region-specific gene expression (Cadherin-6, EphA-7, Id-2, and RZR-beta) developed normally. This provides evidence that patterning mechanisms intrinsic to the neocortex specify the basic organization of its functional subdivisions.
引用
收藏
页码:906 / 909
页数:4
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