Click chemistry assembly of G-quadruplex ligands incorporating a diarylurea scaffold and triazole linkers

被引：32

作者：

Drewe, William C. ^{[1
]}

Neidle, Stephen ^{[1
]}

机构：

[1] Univ London, Sch Pharm, CRUK Biomol Struct Grp, London WC1N 1AX, England

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 42期

关键词：

D O I：

10.1039/b814576h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of diarylurea ligands were designed to interact selectively with G-quadruplexes and were synthesised using copper( I) catalysed 'click' chemistry to incorporate the 1,4-substituted 1,2,3-triazole ring into the core of the ligands; the optimal ligands demonstrate a high degree of selective telomeric G-quadruplex stabilisation and are not cytotoxic in several cancer cell lines.

引用

页码：5295 / 5297

页数：3

共 28 条

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