The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii

被引：606

作者：

Turton, JF

Ward, ME

Woodford, N

Kaufmann, ME

Pike, R

Livermore, DM

Pitt, TL

机构：

[1] Hlth Protect Agcy, Ctr Infect, Lab HealthCare Associated Infect, London NW9 5EQ, England

[2] Hlth Protect Agcy, Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London, England

来源：

FEMS MICROBIOLOGY LETTERS | 2006年 / 258卷 / 01期

关键词：

insertion sequence; Acinetobacter baumannii; OXA carbapenemase;

D O I：

10.1111/j.1574-6968.2006.00195.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

ISAba1 was found in all widespread clones of Acinetobacter baumannii in the United Kingdom. All isolates studied had a bla(OXA-51-like) carbapenemase gene; some also had bla(OXA-23-like) and/or bla(OXA-58-like). Among isolates with bla(OXA-51-like) as sole carbapenemase gene, only those with ISAba1 adjacent to bla(OXA-51-like) were carbapenem resistant. Minor differences in bla(OXA-51-like) sequence were observed in resistant and susceptible isolates. Isolates with bla(OXA-23-like) in addition were consistently resistant to carbapenems; in all of these ISAba1 lay upstream of bla(OXA-23-like), but was not associated with bla(OXA-51-like). These results suggest that ISAba1 is providing the promoter for bla(OXA-51-like) and, probably, for bla(OXA-23-like).

引用

页码：72 / 77

页数：6

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