Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies

被引：102

作者：

Shojaei, Farbod ^{[1
]}

Ferrara, Napoleone ^{[1
]}

机构：

[1] Genentech Inc, San Francisco, CA 94080 USA

来源：

DRUG RESISTANCE UPDATES | 2008年 / 11卷 / 06期

关键词：

Tumor angiogenesis; VEGF; Anti-VEGF; Stromal cells; CD11b+Gr1+cells; Tumor-associated endothelial cells; Endothelial progenitor cells;

D O I：

10.1016/j.drup.2008.09.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Angiogenesis is critical for growth of many tumor types and the development of anti-angiogenic agents opened a new era in cancer therapy. However, similar to other anti-cancer therapies, inherent/acquired resistance to anti-angiogenic drugs may occur in cancer patients leading to disease recurrence. Recent studies in several experimental models suggest that both tumor and non-tumor (stromal) cell types may be involved in the reduced responsiveness to the treatments. The current review focuses on the role of stromal cells in tumor growth and in refractoriness to anti-VEGF treatment. (C) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：219 / 230

页数：12

相关论文

共 175 条

[121] Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle [J].

Ramasamy, Rajesh ;

Fazekasova, Henrietta ;

Lam, Eric W. -F. ;

Soeiro, Ines ;

Lombardi, Giovanna ;

Dazzi, Francesco .

TRANSPLANTATION, 2007, 83 (01) :71-76

[122] GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF) AND GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF) - RECEPTOR BIOLOGY, SIGNAL TRANSDUCTION, AND NEUTROPHIL ACTIVATION [J].

RAPOPORT, AP ;

ABBOUD, CN ;

DIPERSIO, JF .

BLOOD REVIEWS, 1992, 6 (01) :43-57

[123]

RHODIN JAG, 1989, J SUBMICR CYTOL PATH, V21, P1

[124] The involvement of endothelial progenitor cells in tumor angiogenesis [J].

Ribatti, D .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2004, 8 (03) :294-300

[125] Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis [J].

Ridgway, John ;

Zhang, Gu ;

Wu, Yan ;

Stawicki, Scott ;

Liang, Wei-Ching ;

Chanthery, Yvan ;

Kowalski, Joe ;

Watts, Ryan J. ;

Callahan, Christopher ;

Kasman, Ian ;

Singh, Mallika ;

Chien, May ;

Tan, Christine ;

Hongo, Jo-Anne S. ;

de Sauvage, Fred ;

Plowman, Greg ;

Yan, Minhong .

NATURE, 2006, 444 (7122) :1083-1087

[126] Vasculogenesis [J].

Risau, W ;

Flamme, I .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1995, 11 :73-91

[127] Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor [J].

Rodríguez-Manzaneque, JC ;

Lane, TF ;

Ortega, MA ;

Hynes, RO ;

Lawler, J ;

Iruela-Arispe, ML .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (22) :12485-12490

[128] Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer [J].

Sandler, Alan ;

Gray, Robert ;

Perry, Michael C. ;

Brahmer, Julie ;

Schiller, Joan H. ;

Dowlati, Afshin ;

Lilenbaum, Rogerio ;

Johnson, David H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (24) :2542-2550

[129] Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain [J].

Santarelli, Justin G. ;

Udani, Vikram ;

Yung, Yun C. ;

Cheshier, Sam ;

Wagers, Amy ;

Brekken, Rolf A. ;

Weissman, Irving ;

Tse, Victor .

NEUROSURGERY, 2006, 59 (02) :374-381

[130]

Schmielau J, 2001, CANCER RES, V61, P4756

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