Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies

被引：100

作者：

Shojaei, Farbod ^{[1
]}

Ferrara, Napoleone ^{[1
]}

机构：

[1] Genentech Inc, San Francisco, CA 94080 USA

来源：

DRUG RESISTANCE UPDATES | 2008年 / 11卷 / 06期

关键词：

Tumor angiogenesis; VEGF; Anti-VEGF; Stromal cells; CD11b+Gr1+cells; Tumor-associated endothelial cells; Endothelial progenitor cells;

D O I：

10.1016/j.drup.2008.09.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Angiogenesis is critical for growth of many tumor types and the development of anti-angiogenic agents opened a new era in cancer therapy. However, similar to other anti-cancer therapies, inherent/acquired resistance to anti-angiogenic drugs may occur in cancer patients leading to disease recurrence. Recent studies in several experimental models suggest that both tumor and non-tumor (stromal) cell types may be involved in the reduced responsiveness to the treatments. The current review focuses on the role of stromal cells in tumor growth and in refractoriness to anti-VEGF treatment. (C) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：219 / 230

页数：12

相关论文

共 175 条

[31]

Eberhard A, 2000, CANCER RES, V60, P1388

[32] VEGF-targeted therapy: mechanisms of anti-tumour activity [J].

Ellis, Lee M. ;

Hicklin, Daniel J. .

NATURE REVIEWS CANCER, 2008, 8 (08) :579-591

[33] A small molecule-kinase interaction map for clinical kinase inhibitors [J].

Fabian, MA ;

Biggs, WH ;

Treiber, DK ;

Atteridge, CE ;

Azimioara, MD ;

Benedetti, MG ;

Carter, TA ;

Ciceri, P ;

Edeen, PT ;

Floyd, M ;

Ford, JM ;

Galvin, M ;

Gerlach, JL ;

Grotzfeld, RM ;

Herrgard, S ;

Insko, DE ;

Insko, MA ;

Lai, AG ;

Lélias, JM ;

Mehta, SA ;

Milanov, ZV ;

Velasco, AM ;

Wodicka, LM ;

Patel, HK ;

Zarrinkar, PP ;

Lockhart, DJ .

NATURE BIOTECHNOLOGY, 2005, 23 (03) :329-336

[34] Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth [J].

Fahmy, RG ;

Dass, CR ;

Sun, LQ ;

Chesterman, CN ;

Khachigian, LM .

NATURE MEDICINE, 2003, 9 (08) :1026-1032

[35] Vasculogenic mimicry in tumors -: Fact or artifact? [J].

Fausto, N .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (02) :359-359

[36] VEGF and the quest for tumour angiogenesis factors [J].

Ferrara, N .

NATURE REVIEWS CANCER, 2002, 2 (10) :795-803

[37] Vascular endothelial growth factor is essential for corpus luteum angiogenesis [J].

Ferrara, N ;

Chen, H ;

Davis-Smyth, T ;

Gerber, HP ;

Nguyen, TN ;

Peers, D ;

Chisholm, V ;

Hillan, KJ ;

Schwall, RH .

NATURE MEDICINE, 1998, 4 (03) :336-340

[38] Vascular endothelial growth factor: Basic science and clinical progress [J].

Ferrara, N .

ENDOCRINE REVIEWS, 2004, 25 (04) :581-611

[39] PITUITARY FOLLICULAR CELLS SECRETE A NOVEL HEPARIN-BINDING GROWTH-FACTOR SPECIFIC FOR VASCULAR ENDOTHELIAL-CELLS [J].

FERRARA, N ;

HENZEL, WJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 161 (02) :851-858

[40]

Ferrara N, 2005, EXP SUPPL, V94, P209

← 1 2 3 4 5 6 7 8 9 10 →