The Use of Mesenchymal (Skeletal) Stem Cells for Treatment of Degenerative Diseases: Current Status and Future Perspectives

被引：75

作者：

Abdallah, Basem M. ^{[1
]}

Kassem, Moustapha

机构：

[1] Univ So Denmark, Odense Univ Hosp, Mol Endocrinol Lab KMEB, Dept Endocrinol,Med Biotechnol Ctr, DK-5000 Odense C, Denmark

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2009年 / 218卷 / 01期

基金：

英国医学研究理事会;

关键词：

HUMAN BONE-MARROW; STROMAL CELLS; IN-VITRO; MONOLAYER-CULTURES; CARDIAC-FUNCTION; ADIPOSE-TISSUE; LIFE-SPAN; TRANSPLANTATION; REPAIR; OSTEOGENESIS;

D O I：

10.1002/jcp.21572

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Human bone marrow derived-mesenchymal (skeletal) stem (MSC) cells are a group of non-hematopoietic stem cells residing in the perivascular niches in bone marrow. These cells have the capacity to differentiate mainly into mesoderm-type cells such as osteoblasts, chondrocytes and adipocytes and possibly but not proven to non-mesodermal cell types. Recently, there has been an increased interest in understanding the biology of MSC due to their potential use in cell-based therapy for multiple degenerative diseases. Here, we will provide an update on the current status of these novel therapeutic opportunities.

引用

收藏

页码：9 / 12

页数：4

相关论文

共 83 条

[1]

Human mesenchymal stem cells: from basic biology to clinical applications [J].

Abdallah, B. M. ;

Kassem, M. .

GENE THERAPY, 2008, 15 (02) :109-116

[2]

Maintenance of differentiation potential of human bone marrow mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene in despite of extensive proliferation [J].

Abdallah, BM ;

Haack-Sorensen, M ;

Burns, JS ;

Elsnab, B ;

Jakob, F ;

Hokland, P ;

Kassem, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 326 (03) :527-538

[3]

Adult bone marrow-derived cells for cardiac repair - A systematic review and meta-analysis [J].

Abdel-Latif, Ahmed ;

Bolli, Roberto ;

Tleyjeh, Imad M. ;

Montori, Victor M. ;

Perin, Emerson C. ;

Hornung, Carlton A. ;

Zuba-Surma, Ewa K. ;

Al-Mallah, Mouaz ;

Dawn, Buddhadeb .

ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (10) :989-997

[4]

Cotransplantation of ex vivo-expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation [J].

Ball, Lynne M. ;

Bernardo, Maria Ester ;

Roelofs, Helene ;

Lankester, Arjan ;

Cometa, Angela ;

Egeler, R. Maarten ;

Locatelli, Franco ;

Fibbe, Willem E. .

BLOOD, 2007, 110 (07) :2764-2767

[5]

Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo [J].

Bartholomew, A ;

Sturgeon, C ;

Siatskas, M ;

Ferrer, K ;

McIntosh, K ;

Patil, S ;

Hardy, W ;

Devine, S ;

Ucker, D ;

Deans, R ;

Moseley, A ;

Hoffman, R .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (01) :42-48

[6]

Tissue distribution and engraftment of human mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene [J].

Bentzon, JF ;

Stenderup, K ;

Hansen, FD ;

Schroder, HD ;

Abdallah, BM ;

Jensen, TG ;

Kassem, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 330 (03) :633-640

[7]

Human bone marrow-derived mesenchymal stem cells do not undergo transformation after long-term In vitro culture and do not exhibit telomere maintenance mechanisms [J].

Bernardo, Maria Ester ;

Zaffaroni, Nadia ;

Novara, Francesca ;

Cometa, Angela Maria ;

Avanzini, Maria Antonietta ;

Moretta, Antonia ;

Montagna, Daniela ;

Maccario, Rita ;

Villa, Raffaella ;

Daidone, Maria Grazia ;

Zuffardi, Orsetta ;

Locatelli, Franco .

CANCER RESEARCH, 2007, 67 (19) :9142-9149

[8]

Bone marrow stromal stem cells: Nature, biology, and potential applications [J].

Bianco, P ;

Riminucci, M ;

Gronthos, S ;

Robey, PG .

STEM CELLS, 2001, 19 (03) :180-192

[9]

Stem cells in tissue engineering [J].

Bianco, P ;

Robey, PG .

NATURE, 2001, 414 (6859) :118-121

[10]

MESENCHYMAL STEM-CELLS IN IN BONE-DEVELOPMENT, BONE REPAIR, AND SKELETAL REGENERATION THERAPY [J].

BRUDER, SP ;

FINK, DJ ;

CAPLAN, AI .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, 56 (03) :283-294

← 1 2 3 4 5 6 7 8 9 →