A novel Chimpanzee serotype-based adenoviral vector as delivery tool for cancer vaccines

被引：40

作者：

Peruzzi, Daniela ^{[1
]}

Dharmapuri, Sridhar ^{[1
]}

Cirillo, Agostino ^{[1
]}

Bruni, Bruno Ercole ^{[1
]}

Nicosia, Alfredo ^{[2
]}

Cortese, Riccardo ^{[2
]}

Colloca, Stefano ^{[2
]}

Ciliberto, Gennaro ^{[1
]}

La Monica, Nicola ^{[1
]}

Aurisicchio, Luigi ^{[1
]}

机构：

[1] IRBM, Merck Res Labs, Oncol Funct Dept, I-00040 Rome, Italy

[2] Okairos, I-00040 Rome, Italy

来源：

VACCINE | 2009年 / 27卷 / 09期

关键词：

Adenovirus; Vaccination; Tumor immunity; T-CELL RESPONSE; CARCINOEMBRYONIC ANTIGEN; RECOMBINANT ADENOVIRUS; IMMUNE-RESPONSE; NONHUMAN-PRIMATES; NEUTRALIZING ANTIBODIES; ANTI-AD5; IMMUNITY; TRANSGENIC MICE; RHESUS-MONKEYS; GENE-TRANSFER;

D O I：

10.1016/j.vaccine.2008.12.051

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The use of adenovirus (Ad) as vaccine vectors is hindered by pre-existing immunity to human Ads in most of the human population. In order to overcome this limitation, uncommon alternative Ad serotypes need to be utilized, In this study, an E1-E3 deleted recombinant Ad based on the chimpanzee serotype 3 (ChAd3) was engineered to express human carcinoembryonic antigen (CEA) protein or rat neu extracellular/transmembrane domains (ECD.TM). ChAd3 vectors were tested in CEA transgenic (CEA.Tg) and BALB/NeuT mice, which show immunologic tolerance to these antigens. ChAd3 is capable of inducing an immune response comparable to that of hAd5 serotype-based vectors, thus breaking tolerance to tumor associated antigens (TAAs) and achieving anti-tumor effects. Of importance is that ChAd3 can overcome hAd5 pre-existing immunity and work in conjunction with DNA electroporation (DNA-EP) and other Ad vaccines based on common human serotypes. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1293 / 1300

页数：8

共 63 条

[41] Tumor antigen-based immunotherapy and immunoprevention of cancer [J].

Ryan, Sean O. ;

Gantt, Kira R. ;

Finn, Olivera J. .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2007, 142 (03) :179-189

[42] Encapsulation of recombinant adenovirus into alginate microspheres circumvents vector-specific immune response [J].

Sailaja, G ;

HogenEsch, H ;

North, A ;

Hays, J ;

Mittal, SK .

GENE THERAPY, 2002, 9 (24) :1722-1729

[43]

Sakurai F, 2007, CURR GENE THER, V7, P229

[44] Changing the adenovirus fiber for retaining gene delivery efficacy in the presence of neutralizing antibodies [J].

Sarkioja, M. ;

Pesonen, S. ;

Raki, M. ;

Hakkarainen, T. ;

Salo, J. ;

Ahonen, M. T. ;

Kanerva, A. ;

Hemminki, A. .

GENE THERAPY, 2008, 15 (12) :921-929

[45] 2 NEW CANDIDATE ADENOVIRUS SEROTYPES [J].

SCHNURR, D ;

DONDERO, ME .

INTERVIROLOGY, 1993, 36 (02) :79-83

[46] Recent advances in the development of HIV-1 vaccines using replication-incompetent adenovirus vectors [J].

Shiver, JW ;

Emini, EA .

ANNUAL REVIEW OF MEDICINE, 2004, 55 :355-372

[47] Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity [J].

Shiver, JW ;

Fu, TM ;

Chen, L ;

Casimiro, DR ;

Davies, ME ;

Evans, RK ;

Zhang, ZQ ;

Simon, AJ ;

Trigona, WL ;

Dubey, SA ;

Huang, LY ;

Harris, VA ;

Long, RS ;

Liang, XP ;

Handt, L ;

Schleif, WA ;

Zhu, L ;

Freed, DC ;

Persaud, NV ;

Guan, L ;

Punt, KS ;

Tang, A ;

Chen, MC ;

Wilson, KA ;

Collins, KB ;

Heidecker, GJ ;

Fernandez, VR ;

Perry, HC ;

Joyce, JG ;

Grimm, KM ;

Cook, JC ;

Keller, PM ;

Kresock, DS ;

Mach, H ;

Troutman, RD ;

Isopi, LA ;

Williams, DM ;

Xu, Z ;

Bohannon, KE ;

Volkin, DB ;

Montefiori, DC ;

Miura, A ;

Krivulka, GR ;

Lifton, MA ;

Kuroda, MJ ;

Schmitz, JE ;

Letvin, NL ;

Caulfield, MJ ;

Bett, AJ ;

Youil, R .

NATURE, 2002, 415 (6869) :331-335

[48] Artificial envelopment of nonenveloped viruses:: enhancing adenovirus tumor targeting in vivo [J].

Singh, Ravi ;

Tian, Bowen ;

Kostarelos, Kostas .

FASEB JOURNAL, 2008, 22 (09) :3389-3402

[49] STUDIES OF THE HER-2/NEU PROTO-ONCOGENE IN HUMAN-BREAST AND OVARIAN-CANCER [J].

SLAMON, DJ ;

GODOLPHIN, W ;

JONES, LA ;

HOLT, JA ;

WONG, SG ;

KEITH, DE ;

LEVIN, WJ ;

STUART, SG ;

UDOVE, J ;

ULLRICH, A ;

PRESS, MF .

SCIENCE, 1989, 244 (4905) :707-712

[50] HUMAN-BREAST CANCER - CORRELATION OF RELAPSE AND SURVIVAL WITH AMPLIFICATION OF THE HER-2 NEU ONCOGENE [J].

SLAMON, DJ ;

CLARK, GM ;

WONG, SG ;

LEVIN, WJ ;

ULLRICH, A ;

MCGUIRE, WL .

SCIENCE, 1987, 235 (4785) :177-182

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