Guarding against Collateral Damage during Chromatin Transactions

被引：13

作者：

Altmeyer, Matthias ^{[1
]}

Lukas, Jiri ^{[1
]}

机构：

[1] Univ Copenhagen, Chromosome Stabil & Dynam Grp, Dept Dis Biol, Novo Nordisk Fdn Ctr Prot Res, DK-2200 Copenhagen, Denmark

来源：

CELL | 2013年 / 153卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

UBIQUITIN-DEPENDENT RESPONSE; DNA-DAMAGE; LIMITS; RNF169; RIF1;

D O I：

10.1016/j.cell.2013.05.044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Signal amplifications are vital for chromatin function, yet they also bear the risk of transforming into unrestrained, self-escalating, and potentially harmful responses. Examples of inbuilt limitations are emerging, revealing how chromatin transactions are confined within physiological boundaries.

引用

收藏

页码：1431 / 1434

页数：4

相关论文

共 18 条

[1] Spreading Chromatin into Chemical Biology [J].

Allis, C. David ;

Muir, Tom W. .

CHEMBIOCHEM, 2011, 12 (02) :264-279

[2] Ring Finger Protein RNF169 Antagonizes the Ubiquitin-dependent Signaling Cascade at Sites of DNA Damage [J].

Chen, Jie ;

Feng, Wanjuan ;

Jiang, Jun ;

Deng, Yiqun ;

Huen, Michael S. Y. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (33) :27715-27722

[3] Activator-mediated recruitment of the MLL2 methyltransferase complex to the β-globin locus [J].

Demers, Celina ;

Chaturvedi, Chandra-Pralkash ;

Ranish, Jeffrey A. ;

Juban, Gaetan ;

Lai, Patrick ;

Morle, Francois ;

Aebersold, Ruedi ;

Dilworth, F. Jeffrey ;

Groudine, Mark ;

Brand, Marjorie .

MOLECULAR CELL, 2007, 27 (04) :573-584

[4] Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching [J].

Di Virgilio, Michela ;

Callen, Elsa ;

Yamane, Arito ;

Zhang, Wenzhu ;

Jankovic, Mila ;

Gitlin, Alexander D. ;

Feldhahn, Niklas ;

Resch, Wolfgang ;

Oliveira, Thiago Y. ;

Chait, Brian T. ;

Nussenzweig, Andre ;

Casellas, Rafael ;

Robbiani, Davide F. ;

Nussenzweig, Michel C. .

SCIENCE, 2013, 339 (6120) :711-715

[5] A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice [J].

Escribano-Diaz, Cristina ;

Orthwein, Alexandre ;

Fradet-Turcotte, Amelie ;

Xing, Mengtan ;

Young, Jordan T. F. ;

Tkac, Jan ;

Cook, Michael A. ;

Rosebrock, Adam P. ;

Munro, Meagan ;

Canny, Marella D. ;

Xu, Dongyi ;

Durocher, Daniel .

MOLECULAR CELL, 2013, 49 (05) :872-883

[6] TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes [J].

Gudjonsson, Thorkell ;

Altmeyer, Matthias ;

Savic, Velibor ;

Toledo, Luis ;

Dinant, Christoffel ;

Grofte, Merete ;

Bartkova, Jirina ;

Poulsen, Maria ;

Oka, Yasuyoshi ;

Bekker-Jensen, Simon ;

Mailand, Niels ;

Neumann, Beate ;

Heriche, Jean-Karim ;

Shearer, Robert ;

Saunders, Darren ;

Bartek, Jiri ;

Lukas, Jiri ;

Lukas, Claudia .

CELL, 2012, 150 (04) :697-709

[7] Heterochromatin is refractory to γ-H2AX modification in yeast and mammals [J].

Kim, Jung-Ae ;

Kruhlak, Michael ;

Dotiwala, Farokh ;

Nussenzweig, Andre ;

Haber, James E. .

JOURNAL OF CELL BIOLOGY, 2007, 178 (02) :209-218

[8] An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation [J].

Lopez-Contreras, Andres J. ;

Gutierrez-Martinez, Paula ;

Specks, Julia ;

Rodrigo-Perez, Sara ;

Fernandez-Capetillo, Oscar .

JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (03) :455-461

[9] More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance [J].

Lukas, Jiri ;

Lukas, Claudia ;

Bartek, Jiri .

NATURE CELL BIOLOGY, 2011, 13 (10) :1161-1169

[10] Global chromatin compaction limits the strength of the DNA damage response [J].

Murga, Matilde ;

Jaco, Isabel ;

Fan, Yuhong ;

Soria, Rebeca ;

Martinez-Pastor, Barbara ;

Cuadrado, Myriam ;

Yang, Seung-Min ;

Blasco, Maria A. ;

Skoultchi, Arthur I. ;

Fernandez-Capetillo, Oscar .

JOURNAL OF CELL BIOLOGY, 2007, 178 (07) :1101-1108