More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

被引：510

作者：

Lukas, Jiri ^{[1
]}

Lukas, Claudia ^{[1
]}

Bartek, Jiri ^{[1
,2
]}

机构：

[1] Danish Canc Soc, Inst Canc Biol, Ctr Genotox Stress Res, DK-2100 Copenhagen, Denmark

[2] Palacky Univ, Inst Mol & Translat Med, CR-77147 Olomouc, Czech Republic

来源：

NATURE CELL BIOLOGY | 2011年 / 13卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

DOUBLE-STRAND BREAKS; HOMOLOGOUS RECOMBINATION REPAIR; CLASS SWITCH RECOMBINATION; REMODELING FACTOR CHD4; REPLICATION STRESS; CELL-CYCLE; DEPENDENT MONOUBIQUITYLATION; HISTONE UBIQUITINATION; UNCAPPED TELOMERES; SUMO MODIFICATION;

D O I：

10.1038/ncb2344

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Following the discovery in 1998 of gamma-H2AX, the first histone modification induced by DNA damage(1), interest in the changes to chromatin induced by DNA damage has exploded, and a vast amount of information has been generated. However, there has been a discrepancy between our rapidly advancing knowledge of how chromatin responds to DNA damage and the understanding of why cells mobilize large segments of chromatin to protect the genome against destabilizing effects posed by tiny DNA lesions. Recent research has provided insights into these issues and suggests that chromatin responses induced by DNA damage are not simply the accumulation of 'nuclear foci' but are mechanisms required to guard genome integrity.

引用

页码：1161 / 1169

页数：9

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