More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

被引：510

作者：

Lukas, Jiri ^{[1
]}

Lukas, Claudia ^{[1
]}

Bartek, Jiri ^{[1
,2
]}

机构：

[1] Danish Canc Soc, Inst Canc Biol, Ctr Genotox Stress Res, DK-2100 Copenhagen, Denmark

[2] Palacky Univ, Inst Mol & Translat Med, CR-77147 Olomouc, Czech Republic

来源：

NATURE CELL BIOLOGY | 2011年 / 13卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

DOUBLE-STRAND BREAKS; HOMOLOGOUS RECOMBINATION REPAIR; CLASS SWITCH RECOMBINATION; REMODELING FACTOR CHD4; REPLICATION STRESS; CELL-CYCLE; DEPENDENT MONOUBIQUITYLATION; HISTONE UBIQUITINATION; UNCAPPED TELOMERES; SUMO MODIFICATION;

D O I：

10.1038/ncb2344

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Following the discovery in 1998 of gamma-H2AX, the first histone modification induced by DNA damage(1), interest in the changes to chromatin induced by DNA damage has exploded, and a vast amount of information has been generated. However, there has been a discrepancy between our rapidly advancing knowledge of how chromatin responds to DNA damage and the understanding of why cells mobilize large segments of chromatin to protect the genome against destabilizing effects posed by tiny DNA lesions. Recent research has provided insights into these issues and suggests that chromatin responses induced by DNA damage are not simply the accumulation of 'nuclear foci' but are mechanisms required to guard genome integrity.

引用

页码：1161 / 1169

页数：9

共 102 条

[31] BMI1 Confers Radioresistance to Normal and Cancerous Neural Stem Cells through Recruitment of the DNA Damage Response Machinery [J].

Facchino, Sabrina ;

Abdouh, Mohamed ;

Chatoo, Wassim ;

Bernier, Gilbert .

JOURNAL OF NEUROSCIENCE, 2010, 30 (30) :10096-10111

[32] Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction [J].

Fierz, Beat ;

Chatterjee, Champak ;

McGinty, Robert K. ;

Bar-Dagan, Maya ;

Raleigh, Daniel P. ;

Muir, Tom W. .

NATURE CHEMICAL BIOLOGY, 2011, 7 (02) :113-119

[33] Systematic Protein Location Mapping Reveals Five Principal Chromatin Types in Drosophila Cells [J].

Filion, Guillaume J. ;

van Bemmel, Joke G. ;

Braunschweig, Ulrich ;

Talhout, Wendy ;

Kind, Jop ;

Ward, Lucas D. ;

Brugman, Wim ;

de Castro, Ines J. ;

Kerkhoven, Ron M. ;

Bussemaker, Harmen J. ;

van Steensel, Bas .

CELL, 2010, 143 (02) :212-224

[34] Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers. [J].

Fong, Peter C. ;

Boss, David S. ;

Yap, Timothy A. ;

Tutt, Andrew ;

Wu, Peijun ;

Mergui-Roelvink, Marja ;

Mortimer, Peter ;

Swaisland, Helen ;

Lau, Alan ;

O'Connor, Mark J. ;

Ashworth, Alan ;

Carmichael, James ;

Kaye, Stan B. ;

Schellens, Jan H. M. ;

de Bono, Johann S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (02) :123-134

[35] Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks [J].

Galanty, Yaron ;

Belotserkovskaya, Rimma ;

Coates, Julia ;

Polo, Sophie ;

Miller, Kyle M. ;

Jackson, Stephen P. .

NATURE, 2009, 462 (7275) :935-U132

[36] KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response [J].

Goodarzi, Aaron A. ;

Kurka, Thomas ;

Jeggo, Penelope A. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 18 (07) :831-U112

[37] The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax [J].

Goodarzi, Aaron A. ;

Jeggo, Penny ;

Lobrich, Markus .

DNA REPAIR, 2010, 9 (12) :1273-1282

[38] Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler [J].

Gottschalk, Aaron J. ;

Timinszky, Gyula ;

Kong, Stephanie E. ;

Jin, Jingji ;

Cai, Yong ;

Swanson, Selene K. ;

Washburn, Michael P. ;

Florens, Laurence ;

Ladurner, Andreas G. ;

Conaway, Joan W. ;

Conaway, Ronald C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (33) :13770-13774

[39] Chromatin challenges during DNA replication and repair [J].

Groth, Anja ;

Rocha, Walter ;

Verreault, Alain ;

Almouzni, Genevieve .

CELL, 2007, 128 (04) :721-733

[40] Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage [J].

Hajdu, Ildiko ;

Ciccia, Alberto ;

Lewis, Susanna M. ;

Elledge, Stephen J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (32) :13130-13134

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