The medical benefit of 5-HT research

被引：183

作者：

Jones, BJ

Blackburn, TP

机构：

[1] GlaxoSmithKline, Psychiat Res Dept, Harlow CM19 5AW, Essex, England

[2] Synap Pharmaceut Corp, Paramus, NJ 07652 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2002年 / 71卷 / 04期

关键词：

5-HT reuptake inhibitors; 5-HT receptor antagonists; 5-HT receptor agonists; therapeutic applications;

D O I：

10.1016/S0091-3057(01)00745-6

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

5-HT research is now more than 50 years old. and it has generated a wealth of therapeutic agents, some of which have had a major impact on disease management, The 5-HT reuptake inhibitors (SSRIs) are among the most widely prescribed drugs for treating depression and a variety of other disorders including anxiety, social phobia and premenstrual dysphoria (PMD). The other major success stories of 5-HT research are the discovery of 5-HT1B/D receptor agonists for treating migraine and 5-HT3 receptor antagonists for chemotherapy and radiation-induced emesis. The role of 5-HT in the mechanism of action of antipsychotic agents remains a topic of intense research, which promises better treatments for schizophrenia in the future. Compounds interacting with 5-HT1F, 5-HT2C, 5-HT6 and 5-HT7 receptors are currently under investigation and may prove to have important therapeutic applications in the future. (C) 2002 Published by Elsevier Science Inc.

引用

页码：555 / 568

页数：14

共 154 条

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