Microwave-Assisted Cascade Cycloaddition for C-N Bond Formation: An Approach to the Construction of 1,4,5,6-Tetrahydropyrimidine and 2-Imidazoline Derivatives

被引:12
作者
An, Shujuan
Yin, Bing
Liu, Ping
Li, Xiangnan
Li, Chen
Li, Jianli [1 ]
Shi, Zhen
机构
[1] NW Univ Xian, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Shaanxi, Peoples R China
来源
SYNTHESIS-STUTTGART | 2013年 / 45卷 / 18期
基金
中国国家自然科学基金;
关键词
catalysis; cycloaddition; nitrogen heterocycles; nitriles; synthesis; TETRAHYDROPYRIMIDINE DERIVATIVES; EFFICIENT SYNTHESIS; 2-ARYL-N-TOSYLAZETIDINES; CATALYST; INDOLES; DESIGN; ACCESS; RINGS;
D O I
10.1055/s-0033-1339406
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient strategy for the synthesis of various 1,4,5,6-tetrahydropyrimidine and 2-imidazoline derivatives has been reported. The reactions proceeded from nitriles with ethylenediamine or 1,3-diaminopropane via cascade cycloaddition in the presence of CuL2 (L=2-hydroxy-2-phenylacetate) to afford the corresponding 1,4,5,6-tetrahydropyrimidine or 2-imidazoline derivatives under reflux conditions or microwave irradiation in excellent yields.
引用
收藏
页码:2525 / 2532
页数:8
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