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The small GTPase Rap1 is an immediate downstream target for Hoxb4 transcriptional regulation

被引：20
作者：
El-Kadi, ASM
in der Reiden, P
Durston, A
Morgan, R
机构：
[1] St George Hosp, Sch Med, Dept Anat & Dev Biol, London SW17 0RE, England
[2] Netherlands Inst Dev Biol, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands
来源：
MECHANISMS OF DEVELOPMENT | 2002年 / 113卷 / 02期
关键词：
Hoxb4; Rap1; early development; small GTPase; transcriptional control;
D O I：
10.1016/S0925-4773(02)00047-3
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The Hox genes are a family of homedomain-containing transcription factors which determine anteroposterior identity early on in development. Although a lot is now known about their regulation and function, very little is known of their effector (downstream target) genes. Here we show that the small GTPase Rap1 is a direct, negatively regulated target of Hoxb4 and is excluded from Hoxb4 expressing cells. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：131 / 139
页数：9
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