Discrepancies between genital responses and subjective sexual function during testosterone substitution in women with hypothalamic amenorrhea

被引:39
作者
Tuiten, A
Laan, E
Panhuysen, G
Everaerd, W
DeHaan, E
Koppeschaar, H
Vroon, P
机构
[1] UNIV AMSTERDAM,DEPT CLIN PSYCHOL,AMSTERDAM,NETHERLANDS
[2] UNIV UTRECHT HOSP,DEPT ENDOCRINOL,UTRECHT,NETHERLANDS
来源
PSYCHOSOMATIC MEDICINE | 1996年 / 58卷 / 03期
关键词
hypothalamic amenorrhea; eating disorders; testosterone; sexual function; vaginal photoplethysmography;
D O I
10.1097/00006842-199605000-00007
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Psychosexual dysfunction is often suggested the cause of the disturbed eating habits associated with hypothalamic secondary amenorrhea. In contrast, we explored the possibility that impaired sexual function may result from reduced levels of testosterone in amenorrheic subjects as a consequence of particular lifestyles. We studied the effects of erotic stimuli in two experiments, one comparing amenorrheic women to normal controls, the other comparing testosterone substitution to a placebo treatment. The amenorrheic women had a higher incidence of lifestyle and bodily conditions identified as risk factors for amenorrhea (i.e., weight loss before the onset of amenorrhea, low body weight, strenuous exercise, and vegetarianism), lower levels of testosterone, and impaired sexual function compared with normally menstruating women. In an experimental session in which amenorrheic women were asked to produce erotic fantasies, they demonstrated a reduced capacity for sexual fantasizing, less subjective sexual excitement, and less vaginal vasocongestion (vaginal pulse amplitude). However, when exposed to the stronger of two erotic film excerpts, the degree of vaginal response of the amenorrheic women was comparable to that of normally menstruating women. Subsequently, we showed that treatment with testosterone increased vaginal vasocongestion in the same amenorrheic women during exposure to the most potent visual stimulus but had no effect on subjective sexual experience. Testosterone substitution influenced physiological aspects of sexual function, but the psychological level remained unaffected.
引用
收藏
页码:234 / 241
页数:8
相关论文
共 42 条
  • [11] HAIMES AL, 1988, INT J EAT DISORDER, V7, P331, DOI 10.1002/1098-108X(198805)7:3<331::AID-EAT2260070304>3.0.CO
  • [12] 2-B
  • [13] PREOPTIC FORMATION OF 17-BETA-ESTRADIOL IS INFLUENCED BY BEHAVIORAL STIMULI IN THE DOVE
    HUTCHISON, JB
    STEIMER, T
    [J]. BRAIN RESEARCH, 1985, 360 (1-2) : 366 - 369
  • [14] KAPLAN HS, 1993, J SEX MARITAL THER, V19, P3
  • [15] KHURI R, 1981, PSYCHOSOMATICS, V22, P883
  • [16] PERFORMANCE DEMAND AND SEXUAL AROUSAL IN WOMEN
    LAAN, E
    EVERAERD, W
    VANAANHOLD, MT
    REBEL, M
    [J]. BEHAVIOUR RESEARCH AND THERAPY, 1993, 31 (01) : 25 - 35
  • [17] WOMENS SEXUAL AND EMOTIONAL RESPONSES TO MALE-PRODUCED AND FEMALE-PRODUCED EROTICA
    LAAN, E
    EVERAERD, W
    VANBELLEN, G
    HANEWALD, G
    [J]. ARCHIVES OF SEXUAL BEHAVIOR, 1994, 23 (02) : 153 - 169
  • [18] INTERRELATIONSHIPS OF DIET, ATHLETIC ACTIVITY, MENSTRUAL STATUS, AND BONE-DENSITY IN COLLEGIATE WOMEN
    LLOYD, T
    BUCHANAN, JR
    BITZER, S
    WALDMAN, CJ
    MYERS, C
    FORD, BG
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1987, 46 (04) : 681 - 684
  • [19] SEXUALITY OF WOMEN WITH ANOREXIA-NERVOSA
    RABOCH, J
    FALTUS, F
    [J]. ACTA PSYCHIATRICA SCANDINAVICA, 1991, 84 (01) : 9 - 11
  • [20] ROTHSCHILD BS, 1991, INT J EAT DISORDER, V10, P389, DOI 10.1002/1098-108X(199107)10:4&lt