Comparison of peri-implant clinical and radiographic inflammatory parameters and whole salivary destructive inflammatory cytokine profile among obese and non-obese men

被引:31
作者
Abduljabbar, Tariq [1 ]
Al-Sahaly, Faisal [2 ]
Kellesarian, Sergio Varela [3 ]
Kellesarian, Tammy Varela [4 ]
Al-Anazi, Mohammed [2 ]
Al-Khathami, Mohammed [2 ]
Javed, Fawad [3 ]
Vohra, Fahim [1 ]
机构
[1] King Saud Univ, Dept Prosthet Dent Sci, Coll Dent, POB 60169, Riyadh 11545, Saudi Arabia
[2] King Saud Univ, Coll Dent, Intern, Riyadh, Saudi Arabia
[3] Univ Rochester, Eastman Inst Oral Hlth, Dept Gen Dent, Rochester, NY 14627 USA
[4] Barry Univ, Coll Hlth Sci, Miami Shores, FL USA
关键词
Bleeding on probing; Dental implant; Obesity; Inflammation; Cytokine; Bone loss; TYPE-2; DIABETES-MELLITUS; PERIODONTITIS; BIOMARKERS; DISEASES; RISK;
D O I
10.1016/j.cyto.2016.08.017
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
The aim of the present cross-sectional retrospective study was to compare the peri-implant clinical and radiographic inflammatory parameters and whole salivary destructive inflammatory cytokine profile among obese and non-obese men. Thirty-five obese and 37 non-obese men were included. Information regarding age, obesity, systemic health status, and habits was collected using a questionnaire. Clinical examination to evaluate peri-implant parameters and radiographic examination to assess marginal bone loss were conducted. Levels of interleukin (IL)-6 and IL-1 beta in collected un-stimulated whole saliva were measured using enzyme-linked immunosorbent assay. Data was statistically analyzed using Kruskal Wallis test. The mean scores' of peri-implant bleeding on probing (P < 0.05) and peri-implant probing depth (P < 0.05) were significantly higher among obese compared with non-obese individuals. The mean marginal bone loss was also statistically significantly higher among individuals in the test-group compared with the control-group (P < 0.05). Whole salivary IL-10 (P < 0.001) and IL-6 (P < 0.001) levels were significantly higher among individuals in the test-group compared with the control-group. Clinical and radiographic peri-implant inflammatory parameters were worse, and whole salivary IL-6 and IL-10 were higher in obese than non-obese subjects. Obese patients are at greater risk of peri-implant inflammation than non-obese healthy subjects. It is highly recommended that clinicians should educate obese patients seeking implant treatment regarding the association between obesity and peri-implant inflammation. In addition, obese patients with osseointegrated implants must follow strict oral hygiene regimen to prevent inflammation and maintain optimum peri-implant tissue health. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:51 / 56
页数:6
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