The TRAIL apoptotic pathway in cancer onset, progression and therapy

被引:714
作者
Johnstone, Ricky W. [1 ]
Frew, Ailsa J. [1 ]
Smyth, Mark J. [1 ]
机构
[1] Peter MacCallum Canc Ctr, Canc Immunol Program, Melbourne, Vic 3002, Australia
基金
英国医学研究理事会;
关键词
D O I
10.1038/nrc2465
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Triggering of tumour cell apoptosis is the foundation of many cancer therapies. Death receptors of the tumour necrosis factor (TNF) superfamily have been largely characterized, as have the signals that are generated when these receptors are activated. TNF-related apoptosis-inducing ligand (TRAIL) receptors (TRAILR1 and TRAILR2) are promising targets for cancer therapy. Herein we review what is known about the molecular control of TRAIL-mediated apoptosis, the role of TRAIL in carcinogenesis and the potential therapeutic utility of recombinant TRAIL and agonistic antibodies against TRAILR1 and TRAILR2.
引用
收藏
页码:782 / 798
页数:17
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