Triggering of tumour cell apoptosis is the foundation of many cancer therapies. Death receptors of the tumour necrosis factor (TNF) superfamily have been largely characterized, as have the signals that are generated when these receptors are activated. TNF-related apoptosis-inducing ligand (TRAIL) receptors (TRAILR1 and TRAILR2) are promising targets for cancer therapy. Herein we review what is known about the molecular control of TRAIL-mediated apoptosis, the role of TRAIL in carcinogenesis and the potential therapeutic utility of recombinant TRAIL and agonistic antibodies against TRAILR1 and TRAILR2.
机构:
Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Univ London Imperial Coll Sci Technol & Med, Dept Immunol, Tumour Immunol Unit, Div Med, London W12 ONN, England
German Canc Res Ctr, Div Apoptosis Regulat, D-6900 Heidelberg, GermanyFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Grosse-Wilde, Anne
;
Voloshanenko, Oksana
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Univ London Imperial Coll Sci Technol & Med, Dept Immunol, Tumour Immunol Unit, Div Med, London W12 ONN, England
German Canc Res Ctr, Div Apoptosis Regulat, D-6900 Heidelberg, GermanyFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Voloshanenko, Oksana
;
Bailey, S. Lawrence
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Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Bailey, S. Lawrence
;
Longton, Gary M.
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Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USAFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Longton, Gary M.
;
Schaefer, Uta
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Univ London Imperial Coll Sci Technol & Med, Dept Immunol, Tumour Immunol Unit, Div Med, London W12 ONN, England
German Canc Res Ctr, Div Apoptosis Regulat, D-6900 Heidelberg, GermanyFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Schaefer, Uta
;
Csernok, Andreea I.
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Univ London Imperial Coll Sci Technol & Med, Dept Immunol, Tumour Immunol Unit, Div Med, London W12 ONN, England
German Canc Res Ctr, Div Apoptosis Regulat, D-6900 Heidelberg, GermanyFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Csernok, Andreea I.
;
Schuetz, Guenter
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German Canc Res Ctr, Div Mol Biol Cell 1, D-6900 Heidelberg, GermanyFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Schuetz, Guenter
;
Greiner, Erich F.
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German Canc Res Ctr, Div Mol Biol Cell 1, D-6900 Heidelberg, GermanyFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Greiner, Erich F.
;
Kemp, Christopher J.
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Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Kemp, Christopher J.
;
Walczak, Henning
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机构:
Univ London Imperial Coll Sci Technol & Med, Dept Immunol, Tumour Immunol Unit, Div Med, London W12 ONN, England
German Canc Res Ctr, Div Apoptosis Regulat, D-6900 Heidelberg, GermanyFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
机构:
Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA
Hanahan, D
;
Weinberg, RA
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机构:Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA
机构:
Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Univ London Imperial Coll Sci Technol & Med, Dept Immunol, Tumour Immunol Unit, Div Med, London W12 ONN, England
German Canc Res Ctr, Div Apoptosis Regulat, D-6900 Heidelberg, GermanyFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Grosse-Wilde, Anne
;
Voloshanenko, Oksana
论文数: 0引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Dept Immunol, Tumour Immunol Unit, Div Med, London W12 ONN, England
German Canc Res Ctr, Div Apoptosis Regulat, D-6900 Heidelberg, GermanyFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Voloshanenko, Oksana
;
Bailey, S. Lawrence
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h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Bailey, S. Lawrence
;
Longton, Gary M.
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USAFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Longton, Gary M.
;
Schaefer, Uta
论文数: 0引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Dept Immunol, Tumour Immunol Unit, Div Med, London W12 ONN, England
German Canc Res Ctr, Div Apoptosis Regulat, D-6900 Heidelberg, GermanyFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Schaefer, Uta
;
Csernok, Andreea I.
论文数: 0引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Dept Immunol, Tumour Immunol Unit, Div Med, London W12 ONN, England
German Canc Res Ctr, Div Apoptosis Regulat, D-6900 Heidelberg, GermanyFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Csernok, Andreea I.
;
Schuetz, Guenter
论文数: 0引用数: 0
h-index: 0
机构:
German Canc Res Ctr, Div Mol Biol Cell 1, D-6900 Heidelberg, GermanyFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Schuetz, Guenter
;
Greiner, Erich F.
论文数: 0引用数: 0
h-index: 0
机构:
German Canc Res Ctr, Div Mol Biol Cell 1, D-6900 Heidelberg, GermanyFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Greiner, Erich F.
;
Kemp, Christopher J.
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
Kemp, Christopher J.
;
Walczak, Henning
论文数: 0引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Dept Immunol, Tumour Immunol Unit, Div Med, London W12 ONN, England
German Canc Res Ctr, Div Apoptosis Regulat, D-6900 Heidelberg, GermanyFred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA
机构:
Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA
Hanahan, D
;
Weinberg, RA
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h-index: 0
机构:Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA