The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling

被引：162

作者：

Berra, E ^{[1
]}

Ginouvès, A ^{[1
]}

Pouysségur, J ^{[1
]}

机构：

[1] Univ Nice, Ctr Antoine Lacassagne, CNRS,UMR 6543, Inst Signalling Dev Biol & Canc Res, F-06189 Nice, France

来源：

EMBO REPORTS | 2006年 / 7卷 / 01期

关键词：

cell signalling; hypoxia inducible factor; oxygen sensing; prolyl hydroxylase domain protein;

D O I：

10.1038/sj.embor.7400598

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metazoans rapidly respond to changes in oxygen availability by regulating gene expression. The transcription factor hypoxia-inducible-factor (HIF), which controls the expression of several genes, 'senses' the oxygen concentration indirectly through the hydroxylation of two proline residues that earmarks the HIF-alpha subunits for proteasomal degradation. We review the expression, regulation and function of the HIF prolyl hydroxylases or prolyl hydroxylases domain proteins, which are genuine oxygen sensors.

引用

页码：41 / 45

页数：5

共 44 条

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