The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling

被引：162

作者：

Berra, E ^{[1
]}

Ginouvès, A ^{[1
]}

Pouysségur, J ^{[1
]}

机构：

[1] Univ Nice, Ctr Antoine Lacassagne, CNRS,UMR 6543, Inst Signalling Dev Biol & Canc Res, F-06189 Nice, France

来源：

EMBO REPORTS | 2006年 / 7卷 / 01期

关键词：

cell signalling; hypoxia inducible factor; oxygen sensing; prolyl hydroxylase domain protein;

D O I：

10.1038/sj.embor.7400598

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metazoans rapidly respond to changes in oxygen availability by regulating gene expression. The transcription factor hypoxia-inducible-factor (HIF), which controls the expression of several genes, 'senses' the oxygen concentration indirectly through the hydroxylation of two proline residues that earmarks the HIF-alpha subunits for proteasomal degradation. We review the expression, regulation and function of the HIF prolyl hydroxylases or prolyl hydroxylases domain proteins, which are genuine oxygen sensors.

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收藏

页码：41 / 45

页数：5

相关论文

共 44 条

[31] SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons [J].

Lipscomb, EA ;

Sarmiere, PD ;

Freemann, RS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (07) :5085-5092

[32]

Madden SL, 1996, CANCER RES, V56, P5384

[33] The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis [J].

Maxwell, PH ;

Wiesener, MS ;

Chang, GW ;

Clifford, SC ;

Vaux, EC ;

Cockman, ME ;

Wykoff, CC ;

Pugh, CW ;

Maher, ER ;

Ratcliffe, PJ .

NATURE, 1999, 399 (6733) :271-275

[34] Intracellular localisation of human HIF-1α hydroxylases:: implications for oxygen sensing [J].

Metzen, E ;

Berchner-Pfannschmidt, U ;

Stengel, P ;

Marxsen, JH ;

Stolze, I ;

Klinger, M ;

Huang, WQ ;

Wotzlaw, C ;

Hellwig-Bürgel, T ;

Jelkmann, W ;

Acker, H ;

Fandrey, J .

JOURNAL OF CELL SCIENCE, 2003, 116 (07) :1319-1326

[35] Application of bulk high-Tc superconductors to electron beam ion sources:: Present status and outlook [J].

Nakamura, N ;

Terada, M ;

Endo, A ;

Nakai, Y ;

Kanai, Y ;

Komaki, K ;

Yamazaki, Y .

Ninth International Symposium on Electron Beam Ion Sources and Traps and Their Applications, 2004, 2 :1-8

[36] Hypoxia-inducible factor 1 alpha (HIF-1 alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions - Its stabilization by hypoxia depends on redox-induced changes [J].

Salceda, S ;

Caro, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (36) :22642-22647

[37] Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase [J].

Selak, MA ;

Armour, SM ;

MacKenzie, ED ;

Boulahbel, H ;

Watson, DG ;

Mansfield, KD ;

Pan, Y ;

Simon, MC ;

Thompson, CB ;

Gottlieb, E .

CANCER CELL, 2005, 7 (01) :77-85

[38] Hypoxia-inducible factor 1:: master regulator of O2 homeostasis [J].

Semenza, GL .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1998, 8 (05) :588-594

[39] Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression) [J].

Seth, P ;

Krop, I ;

Porter, D ;

Polyak, K .

ONCOGENE, 2002, 21 (05) :836-843

[40] Characterization and comparative analysis of the EGLN gene family [J].

Taylor, MS .

GENE, 2001, 275 (01) :125-132

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