Inhibition of Candida parapsilosis mitochondrial respiratory pathways enhances susceptibility to caspofungin

被引：38

作者：

Chamilos, G

Lewis, RE

Kontoyiannis, DP

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Infect Dis, U402,Infect Control & Employee Hlth, Houston, TX 77030 USA

[2] Univ Houston, Coll Pharm, Houston, TX 77030 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 02期

关键词：

D O I：

10.1128/AAC.50.2.744-747.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Among the Candida species, Candida parapsilosis has a unique mitochondrial respiratory network. The addition of inhibitors of the respiratory pathways in three clinical isolates of C. parapsilosis with high (>= 2-mu g/ml) MICs of caspofungin significantly (fivefold) decreased caspofungin MICs but did not change fluconazole MICs.

引用

页码：744 / 747

页数：4

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