Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16

被引：55

作者：

Pettit, GR

Xu, JP

Hogan, F

Williams, MD

Doubek, DL

Schmidt, JM

Cerny, RL

Boyd, MR

机构：

[1] ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287

[2] UNIV NEBRASKA,NEBRASKA CTR MASS SPECTROMETRY,LINCOLN,NE 68588

[3] NCI,FREDERICK CANC RES & DEV CTR,LAB DRUG DISCOVERY RES & DEV,DTP,DCTDC,FREDERICK,MD 21701

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 08期

关键词：

D O I：

10.1021/np9700230

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An investigation of the sea hare Dolabella auricularia from Papua New Guinea has led to discovery of the new cyclodepsipeptide dolastatin 16 (3) containing two new amino acid units designated dolamethylleuine (Dml) and dolaphenvaline (Dpv). The structural elucidation was achieved by means of high-field (500 MHz) NMR and tandem MS/MS mass spectral interpretations and allowed the assignment cyclo-(Pro-Dpv-Pro-Dml-O-Lac-Pro-O-Hiv-MeVal). The new depsipetide exhibited strong inhibition of growth against a variety of human cancer cell lines.

引用

页码：752 / 754

页数：3

共 18 条

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