The high-affinity IgE receptor (FcεRI):: From physiology to pathology

被引：820

作者：

Kinet, JP ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Boston, MA 02215 USA

[2] Beth Israel Deaconess Med Ctr, Boston, MA USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 1999年 / 17卷

关键词：

receptor; signaling; atopy;

D O I：

10.1146/annurev.immunol.17.1.931

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The high affinity receptor for immunoglobulin E (designated Fc epsilon RI) is the member of the antigen (Ag) receptor superfamily responsible for linking pathogen- or allergen-specific IgEs with cellular immunologic effector functions. This review provides background information on Fc epsilon RI function combined with more detailed summaries of recent progress in understanding specific aspects of Fc epsilon RI biology and biochemistry. Topics covered include the coordination and function of the large multiprotein signaling complexes that are assembled when Fc epsilon RI and other Ag receptors are engaged, new information on human receptor structures and tissue distribution, and the role of the FcR beta chain in signaling and its potential contribution to atopic phenotypes.

引用

页码：931 / 972

页数：46

共 254 条

[21]

BUEHRER BM, 1992, J BIOL CHEM, V267, P3154

[22]

BUEHRER BM, 1993, ADV LIPID RES, V26, P59

[23] NEW NOMENCLATURE FOR THE RETH MOTIF (OR ARH1/TAM/ARAM/YXXL) [J].

CAMBIER, JC ;

DAERON, M ;

FRIDMAN, W ;

GERGELY, J ;

KINET, JP ;

KLAUSNER, R ;

LYNCH, R ;

MALISSEN, B ;

PECHT, I ;

REINHERZ, E ;

RAVETCH, J ;

RETH, M ;

SAMELSON, L ;

SANDOR, M ;

SCHREIBER, A ;

SEED, B ;

TERHORST, C ;

VANDEWINKEL, J ;

WEISS, A .

IMMUNOLOGY TODAY, 1995, 16 (02) :110-110

[24]

CAMBIER JC, 1995, J IMMUNOL, V155, P3281

[25] Phosphoinositide kinases [J].

Carpenter, CL ;

Cantley, LC .

CURRENT OPINION IN CELL BIOLOGY, 1996, 8 (02) :153-158

[26]

Chang EY, 1997, J IMMUNOL, V159, P2624

[27] Interaction of phosphorylated Fc epsilon RI gamma immunoglobulin receptor tyrosine activation motif-based peptides with dual and single SH2 domains of p72(syk) - Assessment of binding parameters and real, time binding kinetics [J].

Chen, T ;

Repetto, B ;

Chizzonite, R ;

Pullar, C ;

Burghardt, C ;

Dharm, E ;

Zhao, AC ;

Carroll, R ;

Nunes, P ;

Basu, M ;

Danho, W ;

Visnick, M ;

Kochan, J ;

Waugh, D ;

Gilfillan, AM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (41) :25308-25315

[28]

CHOI OH, 1993, J IMMUNOL, V151, P5586

[29]

Choi OH, 1996, NATURE, V380, P634

[30] Requirement for the leukocyte-specific adapter protein SLP-76 for normal T-cell development [J].

Clements, JL ;

Yang, B ;

Ross-Barta, SE ;

Eliason, SL ;

Hrstka, RF ;

Williamson, RA ;

Koretzky, GA .

SCIENCE, 1998, 281 (5375) :416-419

← 1 2 3 4 5 6 7 8 9 10 →