Molecular design based on 3D-pharmacophore. Application to 5-HT subtypes receptors

被引：23

作者：

Bureau, R ^{[1
]}

Daveu, C ^{[1
]}

Lancelot, JC ^{[1
]}

Rault, S ^{[1
]}

机构：

[1] Univ Caen, Ctr Etud & Rech Medicament Normandie, F-14032 Caen, France

来源：

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES | 2002年 / 42卷 / 02期

关键词：

D O I：

10.1021/ci0101004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A first definition of a pharmacophore for the serotonin reuptake inhibitors was carried out by considering a three-dimensional model which correlates the chemical structures of series of reuptake inhibitors with their biological affinities. A molecular design was described by analyzing two different 3D serotonin pharmacophores. This successful approach enabled us to consider the design of new serotonin ligands by the same method.

引用

页码：429 / 436

页数：8

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